用于治疗糖尿病的 SGLT2 抑制剂:专利回顾(2019-23)。

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL Expert Opinion on Therapeutic Patents Pub Date : 2024-09-01 Epub Date: 2024-08-02 DOI:10.1080/13543776.2024.2379929
Rahul Baghel, Nikita Chhikara, Pawan Kumar, Akhilesh Kumar Tamrakar
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引用次数: 0

摘要

简介钠-葡萄糖协同转运体 2(SGLT2)抑制剂是美国食品及药物管理局批准的一类糖尿病治疗药物。它们通过诱导葡萄糖尿改善血糖控制。尽管 SGLT2 抑制剂具有强大的降糖活性,但它正在成为具有多方面治疗潜力的药物,其心脏保护、肾脏保护、抗高血压和神经保护活性已得到证实。人们正不断尝试通过结构改造、开发新制剂或与其他药物联用来增强 SGLT2 抑制剂的生物活性,从而更好地控制糖尿病及相关并发症:本综述包括通过 Espacenet 专利检索数据库获取的 2019-2023 年有关 SGLT2 抑制剂的专利申请摘要,重点关注提高糖尿病和代谢并发症的治疗潜力:SGLT2抑制剂为糖尿病提供了一种令人振奋的治疗选择。SGLT2 抑制剂最初是作为抗高血糖药物开发的,现在已产生了多种代谢反应,并已成为具有心脏保护和肾脏保护活性的有前途的抗糖尿病药物。鉴于其独特的治疗特性,SGLT2 抑制剂彻底改变了糖尿病及相关并发症的治疗。有关其对癌症、男性生殖功能障碍和神经退行性疾病的治疗潜力的新证据表明,该领域的进一步研究可能会为其在其他慢性疾病的治疗中的合理应用带来新的前景。
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SGLT2 inhibitors for the treatment of diabetes: a patent review (2019-23).

Introduction: The sodium-glucose co-transporter 2 (SGLT2) inhibitors are FDA-approved class of drugs for diabetes management. They improve glycemic control by inducing glucosuria. Notwithstanding with potent anti-hyperglycemic activity, SGLT2 inhibitors are emerging as drugs with multifaceted therapeutic potential, evidenced for cardioprotective, renoprotective, antihypertensive, and neuroprotective activities. Continuous attempts are being accomplished through structural modification, development of new formulation, or combination with other drugs, to enhance the bioactivity spectrum of SGLT2 inhibitors for better management of diabetes and related complications.

Areas covered: This review comprises a summary of patent applications, acquired using the Espacenet Patent Search database, concerning SGLT2 inhibitors from 2019 to 2023, with focus on improving therapeutic potentials in management of diabetes and metabolic complications.

Expert opinion: SGLT2 inhibitors have provided an exciting treatment option for diabetes. Originally developed as anti-hyperglycemic agents, SGLT2 inhibitors exert pleiotropic metabolic responses and have emerged as promising antidiabetic agents with cardio-protective and reno-protective activities. Given their distinct therapeutic profile, SGLT2 inhibitors have revolutionized the management of diabetes and associated complications. Emerging evidences on their therapeutic potential against cancer, male reproductive dysfunctions, and neurodegenerative diseases indicate that further research in this field may unfold novel prospective on their plausible use in the management of other chronic conditions.

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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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