高血压患者血清 N 端 Pro-B 型钠利尿肽水平与数字热监测的血管反应指数呈负相关。

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Reviews in cardiovascular medicine Pub Date : 2024-06-14 eCollection Date: 2024-06-01 DOI:10.31083/j.rcm2506214

Chien-Hao Hsiao, Chiu-Fen Yang, Ji-Hung Wang, Bang-Gee Hsu

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引用次数: 0

摘要

背景：B型钠尿肽（BNP）可协调内皮的稳态和重塑，在无心力衰竭的普通人群中，内皮功能障碍与心血管死亡率相关。本研究旨在探讨确诊的高血压患者血清 N 端前 B 型钠尿肽（NT-pro-BNP）水平与内皮功能障碍之间的相关性：这项横断面单中心研究包括90名高血压患者。电化学发光免疫测定法测量了 NT-pro-BNP 水平，数字热监测仪计算了血管反应指数（VRI），作为内皮功能的测量指标。在这项研究中，VRI 1.0 表示血管反应性差，1.0 ≤ VRI 2.0 表示血管反应性中等，VRI ≥ 2.0 表示血管反应性良好：在所有高血压患者中，8 名患者（8.9%）的血管反应性较差（VRI 1.0），39 名患者（43.3%）的血管反应性处于中等水平（1.0 ≤ VRI 2.0），其余 43 名患者的血管反应性良好。研究发现，年龄较大（p = 0.012）和血清 NT-pro-BNP 水平升高（p 0.001）与较差的血管反应性有关。在高血压患者中，年龄较大（r = -0.221，p = 0.036）和血清中 NT-pro-BNP 对数变换水平（log-NT-pro-BNP，r = -0.505，p 0.001）与 VRI 值呈负相关。经过多变量线性回归测试，血清 log-NT-pro-BNP 水平（β = -0.505，调整后 R 2 变化 = 0.246，P 0.001）与高血压患者的 VRI 值显著且独立相关：结论：在高血压患者中，血清 log-NT-pro-BNP 水平与根据 VRI 值确定的内皮功能障碍之间呈负相关。

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Serum N-Terminal Pro-B-Type Natriuretic Peptide Level is Negatively Associated with Vascular Reactivity Index by Digital Thermal Monitoring in Patients with Hypertension.

Background: B-type natriuretic peptide (BNP) coordinates endothelial homeostasis and remodeling, with endothelial dysfunction associated with cardiovascular mortality in the general population without heart failure. The objective of this study was to investigate the correlation between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels and endothelial dysfunction among patients diagnosed with hypertension.

Methods: This cross-sectional, single-center study included 90 patients with hypertension. An electrochemiluminescence immunoassay measured NT-pro-BNP levels, and a digital thermal monitoring device calculated a vascular reactivity index (VRI) as a measurement for endothelial function. In this study, VRI $<$ 1.0 denoted poor vascular reactivity, 1.0 $\leq$ VRI $<$ 2.0 indicated intermediate vascular reactivity, and a VRI $\geq$ 2.0 suggested good vascular reactivity.

Results: Out of all the hypertensive patients, eight (8.9%) displayed poor vascular reactivity (VRI $<$ 1.0), while 39 (43.3%) exhibited intermediate vascular reactivity (1.0 $\leq$ VRI $<$ 2.0), leaving the remaining 43 patients demonstrating good vascular reactivity. Older age (p = 0.012) and elevated serum NT-pro-BNP levels (p $<$ 0.001) were found to be associated with poorer vascular reactivity. Older age (r = -0.221, p = 0.036) and log-transformed serum levels of NT-pro-BNP (log-NT-pro-BNP, r = -0.505, p $<$ 0.001) exhibited a negative correlation with VRI values in patients with hypertension. Following a multivariate linear regression test, serum log-NT-pro-BNP level ( $β$ = -0.505, adjusted $R^{2}$ change = 0.246, p $<$ 0.001) emerged as being significantly and independently associated with VRI values among hypertensive patients.

Conclusions: In patients with hypertension, there was a negative association observed between serum log-NT-pro-BNP levels and endothelial dysfunction determined by VRI values.

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.