通过视网膜探索自闭症:自闭症谱系障碍儿童与典型发育儿童的比较研究。

IF 5.3 2区 医学 Q1 BEHAVIORAL SCIENCES Autism Research Pub Date : 2024-07-29 DOI:10.1002/aur.3204
Mingchao Li, Yuexuan Wang, Huiyun Gao, Zhengwang Xia, Chaofan Zeng, Kun Huang, Zhaoqi Zhu, Jianfeng Lu, Qiang Chen, Xiaoyan Ke, Weiwei Zhang
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引用次数: 0

摘要

自闭症谱系障碍(ASD)是一种被广泛认可的神经发育障碍,然而为其早期诊断确定可靠的成像生物标志物仍是一项挑战。考虑到自闭症在眼睛上的特殊表现以及大脑和眼睛之间的相互联系,本研究通过视网膜分析的视角来研究自闭症。我们使用光学相干断层扫描(OCT)/光学相干断层血管造影(OCTA)图像,特别研究了被诊断为 ASD 的儿童与典型发育(TD)儿童视网膜黄斑区的差异。我们的研究结果显示了 ASD 的潜在新特征:ASD 患儿锥体感光器椭圆区(EZ)的厚度明显增加;ASD 患儿视网膜内层大口径动静脉明显减少;EZ 和动静脉的这些变化在左眼比在右眼更为显著。这些关于ASD中感光器改变、血管功能变化和侧化现象的观察结果值得进一步研究,我们希望这项工作能促进对ASD的跨学科理解。
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Exploring autism via the retina: Comparative insights in children with autism spectrum disorder and typical development

Autism spectrum disorder (ASD) is a widely recognized neurodevelopmental disorder, yet the identification of reliable imaging biomarkers for its early diagnosis remains a challenge. Considering the specific manifestations of ASD in the eyes and the interconnectivity between the brain and the eyes, this study investigates ASD through the lens of retinal analysis. We specifically examined differences in the macular region of the retina using optical coherence tomography (OCT)/optical coherence tomography angiography (OCTA) images between children diagnosed with ASD and those with typical development (TD). Our findings present potential novel characteristics of ASD: the thickness of the ellipsoid zone (EZ) with cone photoreceptors was significantly increased in ASD; the large-caliber arteriovenous of the inner retina was significantly reduced in ASD; these changes in the EZ and arteriovenous were more significant in the left eye than in the right eye. These observations of photoreceptor alterations, vascular function changes, and lateralization phenomena in ASD warrant further investigation, and we hope that this work can advance interdisciplinary understanding of ASD.

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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
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