睡眠特征与牙周炎之间没有遗传关联：双向双样本孟德尔随机研究

IF 2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2024-07-29 DOI:10.1080/08869634.2024.2384681

Xin Chen, Zheng Cheng, Junyu Xu, Qianyi Wang, Zhibai Zhao, Qianglin Jiang

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引用次数: 0

摘要

研究目的本研究旨在探讨睡眠特征与牙周炎之间的潜在遗传联系：方法：利用公开的全基因组关联研究数据，包括时间型、白天嗜睡、白天小睡频率、失眠、睡眠持续时间、打鼾和呼吸暂停-低通气指数（AHI），以及单独的牙周炎数据集，进行了双向样本孟德尔随机化（MR）分析：慢性型（OR = 0.929，95% CI = 0.788-1.095）、白天嗜睡（OR = 0.492，95% CI = 0.186-1.306）、白天打盹频率（OR = 1.178，95% CI = 0.745-1.863）、睡眠持续时间（OR = 0.868，95% CI = 0.644-1.169）、AHI（OR = 1.124，95% CI = 0.980-1.289）、失眠（OR = 0.832，95% CI = 0.440-1.573）和打鼾（OR = 0.641，95% CI = 0.198-2.075）对牙周炎没有影响。同样，牙周炎对睡眠特征也没有明显影响：结论：没有证据表明睡眠特征与牙周炎风险之间存在双向遗传关系。

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No genetic association between sleep traits and periodontitis: A bidirectional two-sample Mendelian randomization study.

Objective: This study aimed to investigate the potential genetic link between sleep traits and periodontitis.

Methods: A two-sample bidirectional Mendelian randomization (MR) analysis was conducted using publicly available genome-wide association studies data on chronotype, daytime sleepiness, daytime napping frequency, insomnia, sleep duration, snoring, and the apnea-hypopnea index (AHI), along with a separate dataset on periodontitis.

Results: Chronotype (OR = 0.929, 95% CI = 0.788-1.095), daytime sleepiness (OR = 0.492, 95% CI = 0.186-1.306), daytime napping frequency (OR = 1.178, 95% CI = 0.745-1.863), sleep duration (OR = 0.868, 95% CI = 0.644-1.169), AHI (OR = 1.124, 95% CI = 0.980-1.289), insomnia (OR = 0.832, 95% CI = 0.440-1.573), and snoring (OR = 0.641, 95% CI = 0.198-2.075) had no effect on periodontitis. Similarly, periodontitis demonstrated no significant effect on sleep traits.

Conclusions: There is no evidence of a bidirectional genetic relationship between sleep traits and the risk of periodontitis.

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.