Mohadeseh Bagherabadi, Marie Fleckenstein, Oleksandr Moskalyk, Andrea Belluati, Olga Avrutina and Annette Andrieu-Brunsen
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Grafting and controlled release of antimicrobial peptides from mesoporous silica†
The grafting of antimicrobial peptides onto mesoporous silica particles and their controlled release using a green light-responsive linker, which enables tunable release-concentration-time profiles, is presented. The mesoporous silica surface is functionalized with antimicrobial peptides employing sequential functionalization steps, including the grafting of 3-[(2-propynylcarbamate)propyl]triethoxysilane (PPTEOS) as anchor, boron-dipyrromethene (BODIPY) as photosensitive linker, and C14R peptides as antimicrobial agents. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), attenuated total reflectance infrared (ATR-IR) spectroscopy, and thermogravimetric analysis (TGA) validate the successful fabrication and functionalization of mesoporous silica. The ester-1,2,3-triazole-BODIPY demonstrates high sensitivity to green light and enables C14R antimicrobial peptide release with adjusted concentration-time profiles. Under the applied conditions up to 64 μg mL−1 were released within 40 minutes. The antimicrobial activity of the released C14R on Escherichia coli. BL21(DE3) is demonstrated. Overall, the use of the photosensitive linker not only provides a promising avenue for controlling the release of biomolecules and therapeutics but also opens up opportunities for the development of materials for targeted release in wound dressings, for example.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices