A. Ruram, Happy Chutia, H. Bhattacharyya, Akash Handique
{"title":"梅加拉亚邦东 Khasi Hills 地区年轻成年人血清 25(OH) 维生素 D 缺乏症及其对骨矿物质密度的影响:调查 RANKL/RANK/OPG 系统的参与情况","authors":"A. Ruram, Happy Chutia, H. Bhattacharyya, Akash Handique","doi":"10.4103/jfmpc.jfmpc_2000_23","DOIUrl":null,"url":null,"abstract":"ABSTRACT\n \n \n \n Vitamin D’s precise role in bone mineral density regulation remains elusive. Nevertheless, its deficiency is linked to increased bone turnover through the upregulation of RANK ligands by osteoblasts. This study aimed to (i) evaluate vitamin D status in young adults and (ii) assess the association between vitamin D deficiency and bone turnover markers receptor activator of nuclear factor-κB ligand (RANKL), RANK, and the osteoprotegerin (OPG) in determining bone mineral density.\n \n \n \n This cross-sectional study involved 474 participants from the East Khasi Hills district, Meghalaya. Vitamin D levels were measured using the UniCel DxI 800 system, while OPG, RANK, and RANKL were assessed through enzyme-linked immunosorbent assay (ELISA). Additionally, a whole-body dual X-ray absorptiometry (DEXA) scan determined bone mineral density. Vitamin D deficiency was categorised as <20 ng/ml, insufficiency as 20–29 ng/ml, and sufficiency as ≥30 ng/ml.\n \n \n \n Findings indicated 54.6% vitamin D deficiency and 35.4% insufficiency in young adults. Osteoporosis affected 26%, and 67% exhibited osteopenia. A weak positive correlation was found between vitamin 25(OH) D and bone mineral density T score (r = 0.16, r2 = 0.02, P = 0.44). Additionally, moderately weak correlations were observed between serum vitamin D and OPG (r = –0.42, r2 = 0.18, P < 0.001) and between vitamin D and RANKL (r = –0.13, r2 = 0.01, P = 0.18).\n \n \n \n The study suggests that vitamin D deficiency diminishes bone mineral density by promoting RANKL-RANK osteoclastogenesis and upregulating OPG expression. As young adults form a significant workforce, creating awareness is crucial for maintaining optimal health.\n","PeriodicalId":15856,"journal":{"name":"Journal of Family Medicine and Primary Care","volume":null,"pages":null},"PeriodicalIF":1.1000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum 25(OH) vitamin D deficiency among young adults in the East Khasi Hills district of Meghalaya and its influence on bone mineral density: Investigating the involvement of the RANKL/RANK/OPG system\",\"authors\":\"A. Ruram, Happy Chutia, H. Bhattacharyya, Akash Handique\",\"doi\":\"10.4103/jfmpc.jfmpc_2000_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"ABSTRACT\\n \\n \\n \\n Vitamin D’s precise role in bone mineral density regulation remains elusive. Nevertheless, its deficiency is linked to increased bone turnover through the upregulation of RANK ligands by osteoblasts. This study aimed to (i) evaluate vitamin D status in young adults and (ii) assess the association between vitamin D deficiency and bone turnover markers receptor activator of nuclear factor-κB ligand (RANKL), RANK, and the osteoprotegerin (OPG) in determining bone mineral density.\\n \\n \\n \\n This cross-sectional study involved 474 participants from the East Khasi Hills district, Meghalaya. Vitamin D levels were measured using the UniCel DxI 800 system, while OPG, RANK, and RANKL were assessed through enzyme-linked immunosorbent assay (ELISA). Additionally, a whole-body dual X-ray absorptiometry (DEXA) scan determined bone mineral density. Vitamin D deficiency was categorised as <20 ng/ml, insufficiency as 20–29 ng/ml, and sufficiency as ≥30 ng/ml.\\n \\n \\n \\n Findings indicated 54.6% vitamin D deficiency and 35.4% insufficiency in young adults. Osteoporosis affected 26%, and 67% exhibited osteopenia. A weak positive correlation was found between vitamin 25(OH) D and bone mineral density T score (r = 0.16, r2 = 0.02, P = 0.44). Additionally, moderately weak correlations were observed between serum vitamin D and OPG (r = –0.42, r2 = 0.18, P < 0.001) and between vitamin D and RANKL (r = –0.13, r2 = 0.01, P = 0.18).\\n \\n \\n \\n The study suggests that vitamin D deficiency diminishes bone mineral density by promoting RANKL-RANK osteoclastogenesis and upregulating OPG expression. As young adults form a significant workforce, creating awareness is crucial for maintaining optimal health.\\n\",\"PeriodicalId\":15856,\"journal\":{\"name\":\"Journal of Family Medicine and Primary Care\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Family Medicine and Primary Care\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jfmpc.jfmpc_2000_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PRIMARY HEALTH CARE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Family Medicine and Primary Care","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jfmpc.jfmpc_2000_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PRIMARY HEALTH CARE","Score":null,"Total":0}
引用次数: 0
摘要
摘要 维生素 D 在骨矿物质密度调节中的确切作用仍然难以捉摸。然而,维生素 D 的缺乏与成骨细胞通过上调 RANK 配体增加骨质流失有关。本研究旨在(i)评估青壮年的维生素 D 状态;(ii)评估维生素 D 缺乏与骨转换标志物核因子κB 受体激活剂配体(RANKL)、RANK 和骨保护蛋白(OPG)之间在决定骨矿物质密度方面的关联。 这项横断面研究涉及梅加拉亚邦东 Khasi Hills 地区的 474 名参与者。研究人员使用 UniCel DxI 800 系统测量了维生素 D 水平,并通过酶联免疫吸附试验 (ELISA) 评估了 OPG、RANK 和 RANKL。此外,全身双 X 射线吸收测定法(DEXA)扫描确定了骨矿物质密度。维生素 D 缺乏为 <20 纳克/毫升,不足为 20-29 纳克/毫升,充足为≥30 纳克/毫升。 研究结果表明,54.6%的年轻人缺乏维生素 D,35.4%的年轻人维生素 D 不足。26%的人患有骨质疏松症,67%的人患有骨质疏松症。维生素 25(OH)D 与骨矿物质密度 T 评分之间存在微弱的正相关性(r = 0.16,r2 = 0.02,P = 0.44)。此外,还观察到血清维生素 D 和 OPG(r = -0.42,r2 = 0.18,P <0.001)以及维生素 D 和 RANKL(r = -0.13,r2 = 0.01,P = 0.18)之间存在中度弱相关性。 该研究表明,维生素 D 缺乏会通过促进 RANKL-RANK 破骨细胞生成和上调 OPG 表达来降低骨矿物质密度。青壮年是重要的劳动力群体,因此提高对维生素 D 的认识对于保持最佳健康状态至关重要。
Serum 25(OH) vitamin D deficiency among young adults in the East Khasi Hills district of Meghalaya and its influence on bone mineral density: Investigating the involvement of the RANKL/RANK/OPG system
ABSTRACT
Vitamin D’s precise role in bone mineral density regulation remains elusive. Nevertheless, its deficiency is linked to increased bone turnover through the upregulation of RANK ligands by osteoblasts. This study aimed to (i) evaluate vitamin D status in young adults and (ii) assess the association between vitamin D deficiency and bone turnover markers receptor activator of nuclear factor-κB ligand (RANKL), RANK, and the osteoprotegerin (OPG) in determining bone mineral density.
This cross-sectional study involved 474 participants from the East Khasi Hills district, Meghalaya. Vitamin D levels were measured using the UniCel DxI 800 system, while OPG, RANK, and RANKL were assessed through enzyme-linked immunosorbent assay (ELISA). Additionally, a whole-body dual X-ray absorptiometry (DEXA) scan determined bone mineral density. Vitamin D deficiency was categorised as <20 ng/ml, insufficiency as 20–29 ng/ml, and sufficiency as ≥30 ng/ml.
Findings indicated 54.6% vitamin D deficiency and 35.4% insufficiency in young adults. Osteoporosis affected 26%, and 67% exhibited osteopenia. A weak positive correlation was found between vitamin 25(OH) D and bone mineral density T score (r = 0.16, r2 = 0.02, P = 0.44). Additionally, moderately weak correlations were observed between serum vitamin D and OPG (r = –0.42, r2 = 0.18, P < 0.001) and between vitamin D and RANKL (r = –0.13, r2 = 0.01, P = 0.18).
The study suggests that vitamin D deficiency diminishes bone mineral density by promoting RANKL-RANK osteoclastogenesis and upregulating OPG expression. As young adults form a significant workforce, creating awareness is crucial for maintaining optimal health.