关于合成可乐丽酰胺 A 的研究：构建分子的 C19-C30 段

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-25 DOI:10.1055/a-2373-0372

Nemilikonda Sravan Kumar, Radhakrishna Gattu, B. J. Ramulu, Subhash Ghosh

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引用次数: 0

摘要

通过在片段 9 和 10 之间进行 Sonogashira 偶联，合成了具有神经保护作用的天然产物可乐三色酰胺 A 的 C19-C30 片段。片段 9 的关键步骤是 Maruoka-Keck烯丙基化反应、Evans syn-aldol 反应和 Takai 烯化反应，而片段 10 的关键步骤是糖苷化反应和 Ohira-Bestmann 反应。

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Studies toward the synthesis of Colletotrichamide A: Construction of C19-C30 Segment of the Molecule

The synthesis of C19–C30 segment of the neuroprotective natural product colletotrichamide A has been achieved by performing Sonogashira coupling between the fragments 9 and 10. Maruoka-Keck allylation, Evans syn-aldol and Takai olefinations were used as the key steps for fragment 9 whereas glycosidation and Ohira-Bestmann reactions were used as the pivotal steps for accessing fragment 10.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.