人体不对称的决定因素:不对称的视网膜血管是否预示着身体其他部位的不对称?

Life Pub Date : 2024-07-24 DOI:10.3390/life14080929
Doris Plećaš, Vesna Gotovac Đogaš, O. Polašek, Jelena Škunca Herman
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引用次数: 0

摘要

本研究旨在探索克罗地亚维斯岛、科尔丘拉岛和斯普利特市受试者的视网膜血管不对称(ReVA)模式。不对称的估计是基于对非眼底视网膜眼底照片的地形图像分析,并与九种眼科测量方法、三种基于多普勒的压力指数和八种听力频率进行比较。ReVA还与基因组同源性(ROHs)相关,并用于Cox回归生存模型,其中我们对性别、年龄和合并症的影响进行了调整。在 1873 名受试者中,ReVA 估计值与大多数眼科不对称测量值有显著相关性,与踝肱压指数的相关性较低,与高振幅听力测量不对称的相关性较低(最低 p = 0.020)。ReVA 与 ROH 的数量有明显相关性(r = 0.229,p < 0.001),但与 ROH 长度的相关性较弱(r = 0.101,p < 0.001)。不对称的重叠率很低,只有 107 名受试者(占样本总数的 5.7%)有两次或两次以上属于前 10%。多重不对称并不影响存活率(HR = 0.74,95% 置信区间为 0.45-1.22)。视网膜血管不对称是身体其他部位不对称的不良预测指标。尽管存在视网膜血管不对称并明显与合并症有关,但观察到的视网膜血管不对称程度并不影响该人群的寿命。
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Determinants of Human Asymmetry: Does Asymmetrical Retinal Vasculature Predict Asymmetry Elsewhere in the Body?
The aim of this study was to explore retinal vasculature asymmetry (ReVA) patterns in subjects from the islands of Vis and Korcula and the city of Split, Croatia. Asymmetry estimates were based on topographic image analysis of non-mydriatic retinal fundus photographs and compared with nine ophthalmic measurements, three Doppler-based pressure indices and eight frequencies of audiometry. ReVA was also correlated to the genomic runs of homozygosity (ROHs) and used in a Cox regression survival model, where we adjusted for the effects of sex, age and comorbidity. In 1873 subjects, ReVA estimates were significantly correlated with most ophthalmic asymmetry measures, less strongly with the ankle–brachial pressure index and only modestly with higher-amplitude audiometry asymmetries (lowest p = 0.020). ReVA was significantly correlated with the number of ROHs (r = 0.229, p < 0.001) but less strongly with the ROH length (r = 0.101, p < 0.001). The overlap of asymmetries was low, with only 107 subjects (5.7% of the total sample) who had two or more instances in which they were among the top 10%. Multiple asymmetries did not affect survival (HR = 0.74, 95% confidence intervals 0.45–1.22). Retinal vasculature asymmetry is a poor predictor of asymmetry elsewhere in the body. Despite its existence and apparent association with comorbidities, the observed extent of retinal vasculature asymmetry did not affect the lifespan in this population.
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