Diana Vucevic, Vadim Malis, Yuichi Yamashita, Anya Mesa, Tomosuke Yamaguchi, Suraj Achar, Mitsue Miyazaki, Won C. Bae
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引用次数: 0
摘要
峡部脊柱溶解症的特点是腰椎的关节旁骨骼受到应力损伤,传统的磁共振成像(MRI)常常会漏诊,因此必须进行计算机断层扫描(CT)才能准确诊断。我们对适用于生成类似 CT 图像的磁共振成像技术进行了比较。对无症状和腰背痛(LBP)受试者的腰椎进行 3-Tesla 多回波超短回波时间(UTE)和场回波(FE)序列成像,然后进行简单的平均化和倒置后处理,描绘出类似 CT 外观的脊柱骨骼。通过比较UTE 和 FE 以及单回波和多回波数据,确定了骨骼的对比度-噪声比 (CNR)。从视觉上看,两种序列都以良好的对比度描绘了皮质骨;UTE 处理序列为软组织提供了更平坦的对比度,使其易于与骨区分开来,而 FE 处理图像具有更好的分辨率和骨-肌肉对比度,这对骨折检测非常重要。此外,与单回波图像相比,多回波图像的 CNR 明显更高(p = 0.03)。利用这些技术,在一名枸杞综合症患者身上检测到了进行性脊柱溶解。这项研究证明了使用脊柱骨磁共振成像产生类似 CT 的对比度的可行性。通过使用多回波 UTE 和 FE 序列并结合简单的处理,我们观察到图像质量和对比度有了充分的提高,从而可以检测到脊椎旁骨折。
Ultrashort Echo Time and Fast Field Echo Imaging for Spine Bone Imaging with Application in Spondylolysis Evaluation
Isthmic spondylolysis is characterized by a stress injury to the pars interarticularis bones of the lumbar spines and is often missed by conventional magnetic resonance imaging (MRI), necessitating a computed tomography (CT) for accurate diagnosis. We compare MRI techniques suitable for producing CT-like images. Lumbar spines of asymptomatic and low back pain (LBP) subjects were imaged at 3-Tesla with multi-echo ultrashort echo time (UTE) and field echo (FE) sequences followed by simple post-processing of averaging and inverting to depict spinal bones with a CT-like appearance. The contrast-to-noise ratio (CNR) for bone was determined to compare UTE vs. FE and single-echo vs. multi-echo data. Visually, both sequences depicted cortical bone with good contrast; UTE-processed sequences provided a flatter contrast for soft tissues that made them easy to distinguish from bone, while FE-processed images had better resolution and bone–muscle contrast, which are important for fracture detection. Additionally, multi-echo images provided significantly (p = 0.03) greater CNR compared with single-echo images. Using these techniques, progressive spondylolysis was detected in an LBP subject. This study demonstrates the feasibility of using spine bone MRI to yield CT-like contrast. Through the employment of multi-echo UTE and FE sequences combined with simple processing, we observe sufficient enhancements in image quality and contrast to detect pars fractures.
期刊介绍:
Computation a journal of computational science and engineering. Topics: computational biology, including, but not limited to: bioinformatics mathematical modeling, simulation and prediction of nucleic acid (DNA/RNA) and protein sequences, structure and functions mathematical modeling of pathways and genetic interactions neuroscience computation including neural modeling, brain theory and neural networks computational chemistry, including, but not limited to: new theories and methodology including their applications in molecular dynamics computation of electronic structure density functional theory designing and characterization of materials with computation method computation in engineering, including, but not limited to: new theories, methodology and the application of computational fluid dynamics (CFD) optimisation techniques and/or application of optimisation to multidisciplinary systems system identification and reduced order modelling of engineering systems parallel algorithms and high performance computing in engineering.