使用药用大麻治疗脑瘫:文献综述

D. McDonough, James Charles, Trent Shaw
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摘要

背景 最近的研究证实,药用大麻(MM)可用于治疗具有不同疾病诊断和症状的成年患者的痉挛、睡眠和疼痛。然而,大麻很少被用于治疗成人脑瘫(CP)并发症。本系统性文献综述的目的是在全球范围内探讨 MM 干预疗法,重点是确定使用 MM 治疗 CP 并发症的最佳方法。方法 使用与 MM 治疗和 CP 并发症相关的关键词和同义词进行系统性文献检索。纳入和排除的范围为迪肯图书馆馆藏的 2019 年至 2021 年出版的同行评审学术文献。筛选过程确认了是否符合标准,并确定了参考文献中的其他论文。对论文进行了鉴定和评估,以确保所选论文不存在明显或实际的偏见。结果 从 409 篇文献中筛选出 27 篇进行审查,因为这些文献研究了 MM 治疗对睡眠、疼痛和痉挛并发症患者的益处。目前还没有发现关于对成年 CP 患者使用 MM 的文献。讨论 最近的研究表明,只要对 MM 治疗有充分的了解,患有不同疾病诊断和症状的成年患者就可以使用 MM 来控制睡眠紊乱和改善放松。因此,使用MM治疗成年CP患者的痉挛、疼痛、睡眠、生活质量以及社交和情感健康具有潜在的益处。本综述未分类也未提供资金,其结果仅针对成年 CP 患者,因此不能推广到其他人群。
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The use of medicinal marijuana for treating Cerebral Palsy: a literature review
Background Recent studies have established that Medicinal Marijuana (MM) is beneficial in the treatment of spasms, sleep, and pain in adult patients with varying medical diagnoses and symptoms. However, MM has rarely been used for the treatment of Cerebral Palsy (CP) complications in adults. The aim of this systematic literature review was to explore MM interventions globally, with a focus on identifying the best practice with MM for the treatment of complications of CP. Methods A systematic literature search was performed using keywords and synonyms related to MM treatment and CP complications. Inclusions and exclusions were scoped to scholarly peer reviewed academic literature published 2019 to 2021 located in the Deakin Library collection. A screening process confirmed criteria adherence and identified additional papers in referencing. The papers were appraised and evaluated to ensure selections do not have perceived or actual bias. Results From 409 publications, 27 papers were selected for review because they investigated the benefits of MM treatment for patients with sleep, pain, and spasm complications. There was no literature found on the use of MM for adults with CP. Discussion Recent research has demonstrated that with an informed understanding of MM treatment adult patients with varying medical diagnoses and symptoms can use MM to manage sleep disruption and improve relaxation. Therefore, there are potential benefits for the use of MM in treating spasticity, pain, sleep, quality of life, and social and emotional wellbeing in adult patients with CP. No funding was sort or provided for this review and the results are specific to adults with CP, so they are not to be generalized to other populations.
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