A. N. Sveshnikova, E. A. Adamanskaya, Yu.-D. D. Korobkina, M. A. Panteleev
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引用次数: 0
摘要
嗜中性粒细胞形成的细胞外 DNA 陷阱或 NET(嗜中性粒细胞细胞外陷阱)在许多与血液病、肿瘤和免疫学疾病相关的病理过程中起着至关重要的作用。中性粒细胞和其他白细胞的这种程序性细胞死亡机制似乎也参与了多种疾病的血栓形成和血栓并发症的发病机制。在这篇综述中,我们将讨论在血栓形成和止血过程中导致中性粒细胞活化的细胞内信号传导途径。尽管细胞内的生化反应已被研究得相当透彻,但参与中性粒细胞增多症的特定蛋白质(如 NADPH 氧化酶(NOX)和蛋白-精氨酸脱氨酶(PAD4))的活性调节还需要进一步研究。本文还特别探讨了目前对 NETosis 进行药理调节的方法。
Intracellular signaling involved in the programmed neutrophil cell death leading to the release of extracellular DNA traps in thrombus formation
The formation of extracellular DNA traps by neutrophils, or NETs (neutrophil extracellular traps) plays an essential role in many pathological processes related to hematological, oncological, and immunological diseases. This mechanism of the programmed cell death of neutrophils and other leukocytes appears to be also involved in the pathogenesis of thrombosis and thrombotic complications of a variety of disorders. In this review, we discuss the pathways of intracellular signaling leading to neutrophil activation in thrombosis and hemostasis. Even though the biochemical reactions in a cell are quite well investigated, the regulation of activity of specific proteins involved in NETosis, such as NADPH oxidase (NOX) and protein-arginine deiminase (PAD4), requires further investigation. Current approaches to the pharmacological modulation of NETosis are also specifically addressed here.