{"title":"感觉神经元病的临床和神经生理学特征","authors":"Shuai Yan, Xin Liu, Luxuan Wang","doi":"10.26689/cnr.v2i2.7422","DOIUrl":null,"url":null,"abstract":"Objective: To improve the understanding of clinical and neurophysiological features of sensory neuronopathy and to achieve early diagnosis of the cause of sensory neuronopathy. Methods: This study retrospectively analyzed the clinical manifestations and neurophysiological features of 16 cases of sensory neuronopathy with a clear diagnosis. Results: The study subjects consisted of 6 males and 10 females, aged 42–71 years old, with a mean age of 55 years old. 10 cases were diagnosed with the sensation of walking on cotton, 4 cases complained of numbness and burning sensation in one or both hands, and 2 cases complained of weakness of the limbs. 4 cases had paraneoplastic sensory neuronopathy, 3 cases had autoimmune sensory neuronopathy, 2 cases had platinum-associated sensory neuronopathy, and 7 cases had idiopathic sensory neuronopathy. Sensory nerve action potentials were significantly reduced or lost in 16 patients, 12 cases were widespread in the limbs, and 4 cases were asymmetric. There was no obvious abnormality in motor nerve conduction. Conclusion: Sensory neuronopathies of various etiologies have common characteristic neurophysiological manifestations, and mastering the neurophysiological characteristics of sensory neuronopathies can lead to early identification of sensory neuronopathies.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical and Neurophysiological Features of Sensory Neuronopathy\",\"authors\":\"Shuai Yan, Xin Liu, Luxuan Wang\",\"doi\":\"10.26689/cnr.v2i2.7422\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To improve the understanding of clinical and neurophysiological features of sensory neuronopathy and to achieve early diagnosis of the cause of sensory neuronopathy. Methods: This study retrospectively analyzed the clinical manifestations and neurophysiological features of 16 cases of sensory neuronopathy with a clear diagnosis. Results: The study subjects consisted of 6 males and 10 females, aged 42–71 years old, with a mean age of 55 years old. 10 cases were diagnosed with the sensation of walking on cotton, 4 cases complained of numbness and burning sensation in one or both hands, and 2 cases complained of weakness of the limbs. 4 cases had paraneoplastic sensory neuronopathy, 3 cases had autoimmune sensory neuronopathy, 2 cases had platinum-associated sensory neuronopathy, and 7 cases had idiopathic sensory neuronopathy. Sensory nerve action potentials were significantly reduced or lost in 16 patients, 12 cases were widespread in the limbs, and 4 cases were asymmetric. There was no obvious abnormality in motor nerve conduction. Conclusion: Sensory neuronopathies of various etiologies have common characteristic neurophysiological manifestations, and mastering the neurophysiological characteristics of sensory neuronopathies can lead to early identification of sensory neuronopathies.\",\"PeriodicalId\":87465,\"journal\":{\"name\":\"Clinical neuroscience research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical neuroscience research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26689/cnr.v2i2.7422\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical neuroscience research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26689/cnr.v2i2.7422","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical and Neurophysiological Features of Sensory Neuronopathy
Objective: To improve the understanding of clinical and neurophysiological features of sensory neuronopathy and to achieve early diagnosis of the cause of sensory neuronopathy. Methods: This study retrospectively analyzed the clinical manifestations and neurophysiological features of 16 cases of sensory neuronopathy with a clear diagnosis. Results: The study subjects consisted of 6 males and 10 females, aged 42–71 years old, with a mean age of 55 years old. 10 cases were diagnosed with the sensation of walking on cotton, 4 cases complained of numbness and burning sensation in one or both hands, and 2 cases complained of weakness of the limbs. 4 cases had paraneoplastic sensory neuronopathy, 3 cases had autoimmune sensory neuronopathy, 2 cases had platinum-associated sensory neuronopathy, and 7 cases had idiopathic sensory neuronopathy. Sensory nerve action potentials were significantly reduced or lost in 16 patients, 12 cases were widespread in the limbs, and 4 cases were asymmetric. There was no obvious abnormality in motor nerve conduction. Conclusion: Sensory neuronopathies of various etiologies have common characteristic neurophysiological manifestations, and mastering the neurophysiological characteristics of sensory neuronopathies can lead to early identification of sensory neuronopathies.