{"title":"左乙拉西坦+奥卡西平治疗脑卒中继发性癫痫患者的疗效和安全性评估","authors":"Yujing Huang, Zhenggang Wu","doi":"10.26689/cnr.v2i2.7445","DOIUrl":null,"url":null,"abstract":"Objective: To evaluate the therapeutic efficacy of levetiracetam (LEV) + oxcarbazepine (OXC) for post-stroke secondary epilepsy (PSE) in the elderly. Methods: 92 patients with PSE admitted to the hospital between July 2021 and July 2023 were selected. Random number table grouping was used, with 46 cases in the combination group, selecting LEV + OXC treatment; and 46 cases in the conventional group, selecting OXC treatment, comparing the treatment effect of the two groups. Results: The total effective rate of the combination group was higher than that of the conventional group, and the difference was statistically significant (P < 0.05). Before treatment, in the comparison of the epilepsy-related indexes and blood indexes between the groups, the difference was not statistically significant (P > 0.05). After treatment, the epilepsy-related indicators as well as blood indicators of the combination group were better than those of the conventional group, and the difference was statistically significant (P < 0.05). The adverse reaction rate of the combination group was lower than that of the conventional group, and the difference was statistically significant (P < 0.05). Conclusion: Implementing LEV + OXC therapy for PSE patients can enhance the effectiveness, improve the degree of epilepsy, regulate the blood indexes, and have high therapeutic safety.","PeriodicalId":87465,"journal":{"name":"Clinical neuroscience research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and Safety Evaluation of Levetiracetam + Oxcarbazepine in the Treatment of Patients with Epilepsy Secondary to Stroke\",\"authors\":\"Yujing Huang, Zhenggang Wu\",\"doi\":\"10.26689/cnr.v2i2.7445\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To evaluate the therapeutic efficacy of levetiracetam (LEV) + oxcarbazepine (OXC) for post-stroke secondary epilepsy (PSE) in the elderly. Methods: 92 patients with PSE admitted to the hospital between July 2021 and July 2023 were selected. Random number table grouping was used, with 46 cases in the combination group, selecting LEV + OXC treatment; and 46 cases in the conventional group, selecting OXC treatment, comparing the treatment effect of the two groups. Results: The total effective rate of the combination group was higher than that of the conventional group, and the difference was statistically significant (P < 0.05). Before treatment, in the comparison of the epilepsy-related indexes and blood indexes between the groups, the difference was not statistically significant (P > 0.05). After treatment, the epilepsy-related indicators as well as blood indicators of the combination group were better than those of the conventional group, and the difference was statistically significant (P < 0.05). The adverse reaction rate of the combination group was lower than that of the conventional group, and the difference was statistically significant (P < 0.05). Conclusion: Implementing LEV + OXC therapy for PSE patients can enhance the effectiveness, improve the degree of epilepsy, regulate the blood indexes, and have high therapeutic safety.\",\"PeriodicalId\":87465,\"journal\":{\"name\":\"Clinical neuroscience research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical neuroscience research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26689/cnr.v2i2.7445\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical neuroscience research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26689/cnr.v2i2.7445","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficacy and Safety Evaluation of Levetiracetam + Oxcarbazepine in the Treatment of Patients with Epilepsy Secondary to Stroke
Objective: To evaluate the therapeutic efficacy of levetiracetam (LEV) + oxcarbazepine (OXC) for post-stroke secondary epilepsy (PSE) in the elderly. Methods: 92 patients with PSE admitted to the hospital between July 2021 and July 2023 were selected. Random number table grouping was used, with 46 cases in the combination group, selecting LEV + OXC treatment; and 46 cases in the conventional group, selecting OXC treatment, comparing the treatment effect of the two groups. Results: The total effective rate of the combination group was higher than that of the conventional group, and the difference was statistically significant (P < 0.05). Before treatment, in the comparison of the epilepsy-related indexes and blood indexes between the groups, the difference was not statistically significant (P > 0.05). After treatment, the epilepsy-related indicators as well as blood indicators of the combination group were better than those of the conventional group, and the difference was statistically significant (P < 0.05). The adverse reaction rate of the combination group was lower than that of the conventional group, and the difference was statistically significant (P < 0.05). Conclusion: Implementing LEV + OXC therapy for PSE patients can enhance the effectiveness, improve the degree of epilepsy, regulate the blood indexes, and have high therapeutic safety.