利用透射电子显微镜对血小板进行形态分析

A. A. Kuznetsova, I. I. Kireev, S. Obydennyi
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引用次数: 0

摘要

血小板是人体第二大血细胞。它们的重要功能是在血管损伤部位形成血凝块,防止出血。血小板结构异常可导致各种功能障碍和危及生命的情况。在某些遗传性血小板疾病中,可能需要用透射电子显微镜(TEM)对血小板进行形态学检查。透射电子显微镜技术复杂,由于需要昂贵的设备和训练有素的人员,其使用受到限制。在我们的研究中,我们使用 TEM 评估了 20 名健康捐献者血小板的形态参数。这项研究获得了德米特里-罗加乔夫国家小儿血液学、肿瘤学和免疫学医学研究中心独立伦理委员会和科学委员会的批准。
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A morphometric analysis of platelets using transmission electron microscopy
Platelets are the second most abundant human blood cells. They have an important function to form blood clots at sites of vascular injury to prevent bleeding. Abnormalities of platelet structure can lead to various dysfunctions and life-threatening situations. In some hereditary platelet disorders, morphological examination of platelets with transmission electron microscopy (TEM) may be required. TEM is technically complex, and its use is limited due to the need for expensive equipment and trained personnel. In our study, we assessed the morphometric parameters of platelets obtained from 20 healthy donors using TEM. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.
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来源期刊
Pediatric Hematology/Oncology and Immunopathology
Pediatric Hematology/Oncology and Immunopathology Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.40
自引率
0.00%
发文量
49
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