Thermo gravimetric and Antimicrobial analysis of 4-hydroxy-3-(3-(4-hydroxy-3,5-dimethoxyphenyl)acryloyl)-6-methyl-2H-pyran-2-one chalcone and their metal complexes

In the present paper, the some of first transition series metal complexes derived from 4-hydroxy-3-(3-(4- hydroxy-3,5-dimethoxyphenyl)acryloyl)-6-methyl-2H-pyran-2-one chalcone were synthesized from Dehydroacetic acid and 4-hydroxy-3,5-dimethoxy benzaldehyde (syringaldehyde). The ligand was characterized on the basis of elemental analysis, UV, IR, Mass, 1H NMR and antimicrobial activity. All the complexes were characterized by elemental analysis, UV, magnetic susceptibility measurements, IR, TGA-DTA & antimicrobial activity. The ligand acts as a bidentate chelate and coordinates through two oxygen atoms of ligand i.e complex formed by 1:2 ( metal: ligand ) ratio. The thermal stability of the complexes was studied by thermogravimetry and the decomposition schemes of the complexes are given. The ligand and its metal complexes were screened for antimicrobial activity against Bacillus Cereus, Bacillus Megaterium, Shigellaboydii and Escherichia Coli bacteria, and Saccharomyces Cerevisiae, Aspergillus Oryzae and Penicillium notatum fungi were studied. Antimicrobial activity it is found that the complexes are more active than their parent ligand. Keywords: Transition metal complexes; magnetic susceptibility; Chalcone; Oxygen donar ligand; TGA-DTA; Antimicrobial activity.