Optimizing hybrid deep learning models for drug‐target interaction prediction: A comparative analysis of evolutionary algorithms

In the realm of Drug‐Target Interaction (DTI) prediction, this research investigates and contrasts the efficacy of diverse evolutionary algorithms in fine‐tuning a sophisticated hybrid deep learning model. Recognizing the critical role of DTI in drug discovery and repositioning, we tackle the challenges of binary classification by reframing the problem as a regression task. Our focus lies on the Convolution Self‐Attention Network with Attention‐based bidirectional Long Short‐Term Memory Network (CSAN‐BiLSTM‐Att), a hybrid model combining convolutional neural network (CNN) blocks, self‐attention mechanisms, and bidirectional LSTM layers. To optimize this complex model, we employ Differential Evolution (DE), Particle Swarm Optimization (PSO), Memetic Particle Swarm Optimization Algorithm (MPSOA), Fire Hawk Optimization (FHO), and Artificial Hummingbird Algorithm (AHA). Through thorough comparative analysis, we evaluate the performance of these evolutionary algorithms in enhancing the CSAN‐BiLSTM‐Att model's effectiveness. By examining the strengths and weaknesses of each algorithm, our study aims to provide valuable insights into DTI prediction, identifying the most effective evolutionary algorithm for hyperparameter tuning in advanced deep learning models. Notably, Fire‐hawk optimization (FHO) emerges as particularly promising, achieving the highest Concordance Index (C‐index) as 0.974 for KIBA datasets and 0.894 for DAVIS datasets and demonstrating exceptional accuracy in ranking continuous predictions across both the datasets.