通过在 RAW264.7 细胞中激活依赖于 TLR4 的 JNK，从悬铃木亚种叶中提取的水提取物具有免疫刺激活性

IF 2.3 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Biomedical reports Pub Date : 2024-07-19 DOI:10.3892/br.2024.1821

Hyeok Jin Choi, G. Park, J. Choi, So Jung Park, Jin Hyuk Hwang, Sang Hun Lee, Hae-Yun Kwon, Min Yeong Choi, Jin Boo Jeong

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引用次数: 0

摘要

.Sambucus racemosa subsp.pendula（SRP）是韩国特有的植物，仅分布于郁陵岛。SRP 被广泛用作传统药物和食物来源。然而，目前还缺乏对山姜子药理活性的研究。因此，本研究旨在通过分析SRP叶片（SRPL）的巨噬细胞作用特性及其潜在作用机制，探索其作为天然免疫兴奋剂的潜在用途。在各种提取条件中，用 100% 蒸馏水在 20˚C 下提取的 SRPL（AE20-SRPL）在 RAW264.7 细胞中诱导产生的一氧化氮（NO）最高。因此，进一步的研究使用了 AE20-SRPL。

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Immunostimulatory activity of the aqueous extract from the leaves of Sambucus racemosa subsp. pendula through TLR4‑dependent JNK activation in RAW264.7 cells

. Sambucus racemosa subsp. pendula (SRP) is an endemic plant of Korea, exclusively found on Ulleungdo Island. SRP is widely used as both a traditional medicine and food source. However, there is a lack of research on the phar‑ macological activities of SRP. Therefore, the present study aimed to explore the potential use of SRP leaves (SRPL) as a natural immunostimulant by analyzing its macrophage acti‑ vation properties and the underlying mechanisms of action. Among the various extraction conditions, SRPL (AE20‑SRPL) extracted with 100% distilled water at 20˚C induced the highest nitric oxide (NO) production in RAW264.7 cells. Thus, the further studies were performed using AE20‑SRPL.

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Biomedical reports MEDICINE, RESEARCH & EXPERIMENTAL-

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4.10

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期刊介绍： Biomedical Reports is a monthly, peer-reviewed journal, dedicated to publishing research across all fields of biology and medicine, including pharmacology, pathology, gene therapy, genetics, microbiology, neurosciences, infectious diseases, molecular cardiology and molecular surgery. The journal provides a home for original research, case reports and review articles.