阿尔茨海默病的家族聚集性:流行病学回顾。

Psychiatric developments Pub Date : 1988-01-01
W A Rocca, L Amaducci
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引用次数: 0

摘要

本报告回顾了目前关于阿尔茨海默病(AD)家族聚集性的数据。单家系报告表明,在少数家族中,AD是一种常染色体显性单基因遗传病。家庭研究表明,阿尔茨海默病患者的一级亲属比一般人群或非痴呆受试者群体有更高的阿尔茨海默病患者终生发病率。病例对照研究表明,有家庭成员患有痴呆症的人患AD的风险明显高于没有家庭成员患有痴呆症的人。发现同卵双胞胎的一致性率远低于常染色体显性疾病的预期。这些数据是不确定的;然而,他们建议在未来的病因学研究中应分别考虑三种类型的阿尔茨海默病:常染色体显性、家族性和散发性。阿尔茨海默病按发生类型的亚分类产生的患者群体在病因方面可能更加同质。
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The familial aggregation of Alzheimer's disease: an epidemiological review.

This report reviews current data on the familial aggregation of Alzheimer's disease (AD). Single pedigree reports indicate that in few families AD is inherited as an autosomal dominant single gene disorder. Family studies show that first-degree relatives of AD patients have a higher lifetime incidence of AD than the general population or groups of nondemented subjects. Case-control studies indicate that the risk of developing AD is significantly higher for subjects with family members affected by dementia than for those without. The concordance rate in monozygotic twin pairs was found to be much lower than expected from an autosomal dominant disease. These data are inconclusive; however, they suggest that in future etiologic studies 3 types of AD should be considered separately: autosomal dominant, familial, and sporadic. Subclassification of AD by type of occurrence generates groups of patients which are probably more homogeneous regarding etiology.

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