从灰烬到生命--坚不可摧的 D. radiodurans

Arruda-Neto João DT, Righi Henriette, Lacerda Amanda M
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引用次数: 0

摘要

Deinococcus radiodurans(D. radiodurans)是在 1956 年被意外发现的,当时一罐碎肉被暴露在大剂量的电离伽马辐射下,目的是杀死危险的细菌。这种细菌可以在辐射剂量下存活,甚至可以存活1000倍于对人类致命的辐射剂量。生物学家和生物物理学家经常幽默地称 D. radiodurans 为 "细菌柯南"。这种细菌之所以具有极强的抗辐射能力,是因为它能够保护蛋白质组免受源于水辐射分解的 ROS 的伤害,还能对大量 DNA 损伤进行有效修复。
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From Ashes to Life - The Indestructible D. radiodurans
Deinococcus radiodurans (D. radiodurans) was accidentally discovered in 1956 when cans of ground meat were exposed to massive doses of ionizing gamma radiation, intended to kill dangerous bacteria. The bacterium can survive doses of radiation, even up to 1,000 times that which is deadly to humans. Among biologists and biophysicists, D. radiodurans is often humorously called “Conan the Bacterium.” This extreme radioresistance of the bacterium has been attributed to its ability to protect the proteome from ROS, which originates from water radiolysis, and also to carry out the effective repair of a large amount of DNA damage.
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