免疫肿瘤学时代脂质代谢的精确靶向以及用于癌症治疗的纳米给药系统的最新进展

IF 14.7 1区 医学 Q1 PHARMACOLOGY & PHARMACY Acta Pharmaceutica Sinica. B Pub Date : 2024-11-01 DOI:10.1016/j.apsb.2024.07.021
Hongyan Zhang , Yujie Li , Jingyi Huang , Limei Shen , Yang Xiong
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摘要

在过去十年中,越来越多的研究发现了肿瘤微环境(TME)中独特的脂质代谢失调现象。脂质是多种生物大分子,不仅构成生物膜,还具有信号分子和能量来源的功能。肿瘤微环境中脂类的合成或吸收增加会显著促进肿瘤的发生和增殖。此外,分泌到TME中的脂质还会影响肿瘤驻留免疫细胞(TRICs),从而帮助肿瘤在化疗和免疫治疗中存活下来。本综述旨在重点介绍最近在了解肿瘤细胞和TRICs的脂质代谢方面取得的进展,特别强调外源性脂质吸收和内源性脂质从头合成。以脂质代谢为靶点干预抗癌疗法为癌症治疗提供了一条前景广阔的治疗途径。纳米给药系统(NDDSs)已成为一种通过重构肿瘤代谢来最大限度提高抗肿瘤效果的手段。本综述全面综述了近期有关开发针对肿瘤脂质代谢的 NDDSs 的文献,尤其是在肿瘤免疫疗法方面。它涵盖了四个关键方面:重塑脂质摄取、重塑脂肪分解、重塑脂肪酸氧化(FAO)和重塑细胞膜上的脂质组成。综述最后讨论了这一新兴研究领域的未来前景和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy
Over the past decade, research has increasingly identified unique dysregulations in lipid metabolism within the tumor microenvironment (TME). Lipids, diverse biomolecules, not only constitute biological membranes but also function as signaling molecules and energy sources. Enhanced synthesis or uptake of lipids in the TME significantly promotes tumorigenesis and proliferation. Moreover, lipids secreted into the TME influence tumor-resident immune cells (TRICs), thereby aiding tumor survival against chemotherapy and immunotherapy. This review aims to highlight recent advancements in understanding lipid metabolism in both tumor cells and TRICs, with a particular emphasis on exogenous lipid uptake and endogenous lipid de novo synthesis. Targeting lipid metabolism for intervention in anticancer therapies offers a promising therapeutic avenue for cancer treatment. Nano-drug delivery systems (NDDSs) have emerged as a means to maximize anti-tumor effects by rewiring tumor metabolism. This review provides a comprehensive overview of recent literature on the development of NDDSs targeting tumor lipid metabolism, particularly in the context of tumor immunotherapy. It covers four key aspects: reprogramming lipid uptake, reprogramming lipolysis, reshaping fatty acid oxidation (FAO), and reshuffling lipid composition on the cell membrane. The review concludes with a discussion of future prospects and challenges in this burgeoning field of research.
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来源期刊
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B Pharmacology, Toxicology and Pharmaceutics-General Pharmacology, Toxicology and Pharmaceutics
CiteScore
22.40
自引率
5.50%
发文量
1051
审稿时长
19 weeks
期刊介绍: The Journal of the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association oversees the peer review process for Acta Pharmaceutica Sinica. B (APSB). Published monthly in English, APSB is dedicated to disseminating significant original research articles, rapid communications, and high-quality reviews that highlight recent advances across various pharmaceutical sciences domains. These encompass pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis, and pharmacokinetics. A part of the Acta Pharmaceutica Sinica series, established in 1953 and indexed in prominent databases like Chemical Abstracts, Index Medicus, SciFinder Scholar, Biological Abstracts, International Pharmaceutical Abstracts, Cambridge Scientific Abstracts, and Current Bibliography on Science and Technology, APSB is sponsored by the Institute of Materia Medica, Chinese Academy of Medical Sciences, and the Chinese Pharmaceutical Association. Its production and hosting are facilitated by Elsevier B.V. This collaborative effort ensures APSB's commitment to delivering valuable contributions to the pharmaceutical sciences community.
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