TRPC1:海马的管家

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2024-07-27 DOI:10.1016/j.ceca.2024.102933
Julia Skerjanz , Lena Bauernhofer , Kerstin Lenk , Anita Emmerstorfer-Augustin , Gerd Leitinger , Florian Reichmann , Thomas Stockner , Klaus Groschner , Oleksandra Tiapko
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引用次数: 0

摘要

非选择性阳离子通道 TRPC1 在大脑中高度表达。最新研究表明,神经元 TRPC1 与 TRPC4 和 TRPC5 形成异构复合物,一小部分作为同构复合物存在,主要存在于 ER 中。鉴于大多数研究都集中于异构 TRPC1/4/5 复合物的作用,因此研究同构 TRPC1 在维持大脑稳态中的特殊作用至关重要。这篇综述重点介绍了有关大脑中 TRPC1 的最新发现,重点是海马体,并汇编了有关 TRPC1/4/5 亚家族中调节剂及其结合位点的最新数据,以激发有关更具选择性的 TRPC1 配体的新研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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TRPC1: The housekeeper of the hippocampus

The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the specific role of homomeric TRPC1 in maintaining brain homeostasis. This review highlights recent findings on TRPC1 in the brain, with a focus on the hippocampus, and compiles the latest data on modulators and their binding sites within the TRPC1/4/5 subfamily to stimulate new research on more selective TRPC1 ligands.

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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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