{"title":"B 细胞表位图谱：通往更好的疫苗和治疗性抗体之路","authors":"Asha Joanne De Leon , M. Christian Tjiam , Yu Yu","doi":"10.1016/j.bbagen.2024.130674","DOIUrl":null,"url":null,"abstract":"<div><p>B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases. Here, we discuss conventional approaches and emerging techniques that are used to map B-cell epitopes.</p></div>","PeriodicalId":8800,"journal":{"name":"Biochimica et biophysica acta. General subjects","volume":"1868 10","pages":"Article 130674"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"B cell epitope mapping: The journey to better vaccines and therapeutic antibodies\",\"authors\":\"Asha Joanne De Leon , M. Christian Tjiam , Yu Yu\",\"doi\":\"10.1016/j.bbagen.2024.130674\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases. Here, we discuss conventional approaches and emerging techniques that are used to map B-cell epitopes.</p></div>\",\"PeriodicalId\":8800,\"journal\":{\"name\":\"Biochimica et biophysica acta. General subjects\",\"volume\":\"1868 10\",\"pages\":\"Article 130674\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et biophysica acta. General subjects\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S030441652400117X\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. General subjects","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S030441652400117X","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
B 细胞表位图谱是一种可以确定和描述 B 细胞受体和分泌抗体的特定抗原结合位点的方法。确定 B 细胞克隆结合的氨基酸抗原群的能力提供了前所未有的细节，有助于开发新型有效的疫苗靶点和治疗各种疾病的抗体。在此，我们将讨论用于绘制 B 细胞表位图的传统方法和新兴技术。
B cell epitope mapping: The journey to better vaccines and therapeutic antibodies
B-cell epitope mapping is an approach that can identify and characterise specific antigen binding sites of B-cell receptors and secreted antibodies. The ability to determine the antigenic clusters of amino acids bound by B-cell clones provides unprecedented detail that will aid in developing novel and effective vaccine targets and therapeutic antibodies for various diseases. Here, we discuss conventional approaches and emerging techniques that are used to map B-cell epitopes.
期刊介绍：
BBA General Subjects accepts for submission either original, hypothesis-driven studies or reviews covering subjects in biochemistry and biophysics that are considered to have general interest for a wide audience. Manuscripts with interdisciplinary approaches are especially encouraged.
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