食用蜂胶对身体成分和血压的影响:系统回顾与剂量反应荟萃分析

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Current Therapeutic Research-clinical and Experimental Pub Date : 2024-01-01 DOI:10.1016/j.curtheres.2024.100754
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引用次数: 0

摘要

引言和目的关于食用蜂胶对身体成分和血压(BP)影响的研究结果并不一致。本系统综述和剂量反应荟萃分析汇编了有关补充蜂胶如何影响成人身体成分和血压水平的随机对照试验(RCTs)数据。研究纳入了评估食用蜂胶对体重、体重指数(BMI)、腰围(WC)、臀围(HC)、腰臀比(WHR)、脂肪量(FM)、收缩压(SBP)和舒张压(DBP)影响的研究性临床试验。我们使用随机效应模型确定了汇总效应大小。补充蜂胶可显著降低体重(加权平均差 [WMD]:-0.37 千克;95% 置信区间 [CI]:-0.63 至 -0.12)和 BMI(WMD:-0.11 千克/平方米;95% 置信区间 [CI]:-0.13 至 -0.09)。但是,对腹围、体重指数、FM、HC、SBP 和 DBP 水平没有明显影响。剂量-反应分析表明,蜂胶剂量与体重指数之间存在显著的非线性关系(P = 0.020)。此外,BMI(P = 0.047)和WC(P = 0.004)的下降趋势一直持续到干预8周,然后这种影响趋于平稳。然而,应该注意的是,补充蜂胶的抗肥胖作用很小,可能不会达到临床重要性。因此,今后需要进行设计合理、样本量大的研究,以探讨蜂胶对成年人身体成分和血压的影响。
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The Effects of Propolis Consumption on Body Composition and Blood Pressure: A Systematic Review and Dose-Response Meta-Analysis

Introduction and Aim

Research on the effects of propolis consumption on body composition, and blood pressure (BP) has produced inconsistent results. This systematic review and dose-response meta-analysis was carried out to compile the data from the randomized controlled trials (RCTs) on how propolis supplementation affects body composition, and BP level in adults.

Materials and Methods

A systematic literature search was conducted using electronic databases, including PubMed, Embase, Scopus, Web of Science, and Cochrane library, up to January 2024. The RCTs, evaluating the effects of propolis consumption on weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), fat mass (FM), systolic BP (SBP), and diastolic BP (DBP), were included in the study. We used the random-effects model to establish the pooled effect size.

Results

A total of 22 RCTs involving 1082 participants were included in the study. Propolis supplementation demonstrated significant reductions in weight (weighted mean difference [WMD]: –0.37 kg; 95% confidence interval [CI]: –0.63 to –0.12), and BMI (WMD: –0.11 kg/m2; 95% CI: –0.13 to –0.09). However, there were no significant effects on WC, WHR, FM, HC, SBP, and DBP levels. The dose-response analysis revealed a significant nonlinear relationship between propolis dosage and WC (P = 0.020). Moreover, the BMI (P = 0.047) and WC (P = 0.004) reduction trend continues until 8 weeks of intervention and then this impact plateaued.

Conclusions

Supplementation with propolis seems to be effective in reducing weight and BMI. However, it should be noted that the anti-obesity properties of propolis supplementation were small and may not reach clinical importance. Therefore, future well-designed studies with a large sample size are needed to investigate the effect of propolis on body composition and BP in adults.

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期刊介绍: We also encourage the submission of manuscripts presenting preclinical and very preliminary research that may stimulate further investigation of potentially relevant findings, as well as in-depth review articles on specific therapies or disease states, and applied health delivery or pharmacoeconomics. CTR encourages and supports the submission of manuscripts describing: • Interventions designed to understand or improve human health, disease treatment or disease prevention; • Studies that focus on problems that are uncommon in resource-rich countries; • Research that is "under-published" because of limited access to monetary resources such as English language support and Open Access fees (CTR offers deeply discounted English language editing); • Republication of articles previously published in non-English journals (eg, evidence-based guidelines) which could be useful if translated into English; • Preclinical and clinical product development studies that are not pursued for further investigation based upon early phase results.
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