粉红胡椒(Schinus terebinthifolius Raddi)叶的植物化学成分概况、抗氧化剂筛选和对糖尿病小鼠的抗糖尿病作用

IF 4.8 Q1 AGRICULTURE, MULTIDISCIPLINARY Journal of Agriculture and Food Research Pub Date : 2024-07-26 DOI:10.1016/j.jafr.2024.101309
Zakia Zouaoui , Abdelmounaim Laabar , Sara El Asri , Abdelhamid Ennoury , Imad Kabach , Luigi Mondello , Francesco Cacciola , Khalid Taghzouti , Mohamed Nhiri , Naima Nhiri
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引用次数: 0

摘要

目前的这项研究探讨了粉红胡椒(Schinus terebinthifolius Raddi)叶片对糖尿病小鼠糖尿病相关损害的健康益处。与非糖尿病小鼠相比,研究人员观察到血糖、总胆固醇、低密度脂蛋白、肝脏丙二醛(MDA)、过氧化物(H2O2)和肾脏高级糖化终产物(AGE)均有明显增加。此外,高血糖小鼠的高密度脂蛋白胆固醇水平和抗氧化酶(即过氧化氢酶、谷胱甘肽还原酶、谷胱甘肽过氧化物酶以及超氧化物歧化酶)也明显下降。连续21天使用Sinus terebinthifolius Raddi叶片甲醇提取物(150和250毫克/千克)可显著降低血糖异常小鼠肾脏中的血糖、总胆固醇、低密度脂蛋白、肝脏丙二醛(MDA)、H2O2和AGE水平;提高血清高密度脂蛋白水平,增强肝脏氧化还原调节酶的活性。这些研究结果表明,STME 能够缓解与糖尿病相关的高血糖症状。这些数据表明,服用莱菔子叶提取物有助于预防糖尿病病理过程中由糖化、氧化应激和高脂血症引起的改变和功能障碍。总体结果表明,Schinus terebinthifolius Raddi 叶片中的植物化学物质可能是寻找新的抗糖尿病疗法的一个很有前景的治疗机会。
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Phytochemical profile, antioxidant screening, and antidiabetic effect of pink pepper (Schinus terebinthifolius Raddi) leaves in diabetic mice

This current research explores the health benefits of pink pepper (Schinus terebinthifolius Raddi) leaves linked to damage associated with diabetes in diabetic mice. An interesting increase in blood glycemia, total cholesterol, low-density lipoprotein, hepatic malondialdehyde (MDA), peroxide (H2O2), and renal advanced glycated end products (AGE) in comparison with the non-diabetic mice was observed. Additionally, a decrease in the high-density lipoprotein cholesterol level and antioxidant enzymes namely catalase, glutathione reductase, glutathione peroxidase, as well as superoxide dismutase in mice with hyperglycemia was appreciated, as well. The treatment with Schinus terebinthifolius Raddi methanolic extract (STME) from leaves (150 and 250 mg kg−1) for 21 days reduced markedly blood glucose, TC, LDL, hepatic malondialdehyde (MDA), H2O2 and AGE levels in kidneys of mice with abnormally glucose level; it elevated serum HDL degree and boosted the activity of hepatic redox-regulating enzymes in diabetic mice. These findings exhibit the capacity of the STME to mitigate diabetes-related hyperglycemia. The data proposed that the administration of Schinus terebinthifolius Raddi leaves extract can be useful in preventing alterations and dysfunction caused by glycation, oxidative stress, and hyperlipidemia in the pathology of diabetes. The overall results imply that phytochemical compounds of Schinus terebinthifolius Raddi leaves may represent a promising therapeutic opportunity in the search for new anti-diabetic treatments.

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来源期刊
CiteScore
5.40
自引率
2.60%
发文量
193
审稿时长
69 days
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