{"title":"原发性周围神经过度兴奋综合征中复合肌肉动作电位或 F 波后放电的特征。","authors":"Youfang Hu, Qingyun Ding, Xinhong Feng, Wu Yimin, Dongchao Shen, Jiayu Shi, Shuang Wu, Liying Cui, Yuzhou Guan","doi":"10.1002/mus.28220","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction/aims: </strong>F-wave testing frequently reveals after-discharges of varied morphologies in patients with primary peripheral nerve hyperexcitability syndrome (PNHS), although reports are scant. This study aimed to explore the morphological characteristics of the after-discharges during F-wave tests in PNHS, and to assess the association between after-discharges and the disease classification.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients diagnosed with PNHS between 2014 and 2022. The morphological characteristic and duration of after-discharges during F-wave tests were analyzed. After-discharges in the Morvan syndrome group were compared with those in non-Morvan group, and between groups with positive or negative voltage-gated potassium channel (VGKC) complex antibodies.</p><p><strong>Results: </strong>Twenty-nine patients were included in the study, of which 25 exhibited after-discharges. All after-discharges in Morvan patients occurred following compound muscle action potential (CMAP). In non-Morvan patients, after-discharges occurred following F-wave (32%) and CMAP (47%). The durations of after-discharges following CMAP were significantly prolonged in Morvan (54.2 ± 18.8 ms) compared to non-Morvan patients (34.5 ± 15.0 ms). The majority of antibody-positive patients (18/20) exhibited after-discharges following CMAP, whereas 67% of antibody-negative patients (6/9) showed after-discharges following F-wave.</p><p><strong>Discussion: </strong>The varying presentations of after-discharges, including their location (after CMAP or F-wave) and the duration of after-discharge can assist in clinically classifying PNHS.</p>","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome.\",\"authors\":\"Youfang Hu, Qingyun Ding, Xinhong Feng, Wu Yimin, Dongchao Shen, Jiayu Shi, Shuang Wu, Liying Cui, Yuzhou Guan\",\"doi\":\"10.1002/mus.28220\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction/aims: </strong>F-wave testing frequently reveals after-discharges of varied morphologies in patients with primary peripheral nerve hyperexcitability syndrome (PNHS), although reports are scant. This study aimed to explore the morphological characteristics of the after-discharges during F-wave tests in PNHS, and to assess the association between after-discharges and the disease classification.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients diagnosed with PNHS between 2014 and 2022. The morphological characteristic and duration of after-discharges during F-wave tests were analyzed. After-discharges in the Morvan syndrome group were compared with those in non-Morvan group, and between groups with positive or negative voltage-gated potassium channel (VGKC) complex antibodies.</p><p><strong>Results: </strong>Twenty-nine patients were included in the study, of which 25 exhibited after-discharges. All after-discharges in Morvan patients occurred following compound muscle action potential (CMAP). In non-Morvan patients, after-discharges occurred following F-wave (32%) and CMAP (47%). The durations of after-discharges following CMAP were significantly prolonged in Morvan (54.2 ± 18.8 ms) compared to non-Morvan patients (34.5 ± 15.0 ms). 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引用次数: 0
摘要
导言/目的:原发性周围神经兴奋性减退综合征(PNHS)患者的F波测试经常出现形态各异的后放电,但相关报道很少。本研究旨在探讨原发性周围神经过度兴奋综合征(PNHS)患者在 F 波测试中的后放电形态特征,并评估后放电与疾病分类之间的关联:我们对2014年至2022年期间确诊的PNHS患者进行了回顾性分析。方法:我们对2014年至2022年期间确诊的PNHS患者进行了回顾性分析,分析了F波检查中后放电的形态特征和持续时间。比较莫文综合征组和非莫文组的后放电,以及电压门控钾通道(VGKC)复合抗体阳性或阴性组之间的后放电:研究共纳入 29 名患者,其中 25 人出现了后放电。莫凡患者的所有后放电都发生在复合肌肉动作电位(CMAP)之后。在非莫文患者中,余放发生在 F 波(32%)和 CMAP(47%)之后。与非莫文患者(34.5 ± 15.0 毫秒)相比,莫文患者 CMAP 后放电的持续时间明显延长(54.2 ± 18.8 毫秒)。大多数抗体阳性患者(18/20)在 CMAP 后出现后放,而 67% 的抗体阴性患者(6/9)在 F 波后出现后放:讨论:后放电的不同表现形式,包括其位置(CMAP 或 F 波后)和后放电持续时间,有助于对 PNHS 进行临床分类。
Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome.
Introduction/aims: F-wave testing frequently reveals after-discharges of varied morphologies in patients with primary peripheral nerve hyperexcitability syndrome (PNHS), although reports are scant. This study aimed to explore the morphological characteristics of the after-discharges during F-wave tests in PNHS, and to assess the association between after-discharges and the disease classification.
Methods: We conducted a retrospective analysis of patients diagnosed with PNHS between 2014 and 2022. The morphological characteristic and duration of after-discharges during F-wave tests were analyzed. After-discharges in the Morvan syndrome group were compared with those in non-Morvan group, and between groups with positive or negative voltage-gated potassium channel (VGKC) complex antibodies.
Results: Twenty-nine patients were included in the study, of which 25 exhibited after-discharges. All after-discharges in Morvan patients occurred following compound muscle action potential (CMAP). In non-Morvan patients, after-discharges occurred following F-wave (32%) and CMAP (47%). The durations of after-discharges following CMAP were significantly prolonged in Morvan (54.2 ± 18.8 ms) compared to non-Morvan patients (34.5 ± 15.0 ms). The majority of antibody-positive patients (18/20) exhibited after-discharges following CMAP, whereas 67% of antibody-negative patients (6/9) showed after-discharges following F-wave.
Discussion: The varying presentations of after-discharges, including their location (after CMAP or F-wave) and the duration of after-discharge can assist in clinically classifying PNHS.
期刊介绍:
Muscle & Nerve is an international and interdisciplinary publication of original contributions, in both health and disease, concerning studies of the muscle, the neuromuscular junction, the peripheral motor, sensory and autonomic neurons, and the central nervous system where the behavior of the peripheral nervous system is clarified. Appearing monthly, Muscle & Nerve publishes clinical studies and clinically relevant research reports in the fields of anatomy, biochemistry, cell biology, electrophysiology and electrodiagnosis, epidemiology, genetics, immunology, pathology, pharmacology, physiology, toxicology, and virology. The Journal welcomes articles and reports on basic clinical electrophysiology and electrodiagnosis. We expedite some papers dealing with timely topics to keep up with the fast-moving pace of science, based on the referees'' recommendation.