Filip Pirsl, Keri Calkins, Jacqueline E Rudolph, Eryka Wentz, Xiaoqiang Xu, Bryan Lau, Corinne E Joshu
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引用次数: 0
摘要
据报道,与未感染 HIV 的男性相比,感染 HIV 的男性的前列腺癌(PCa)发病率较低,原因不明。我们按医疗补助受益人的 HIV 感染状况对 PCa 发病率进行了描述,以便对在社会经济特征和医疗保健服务方面相似的男性 HIV 感染者和非 HIV 感染者进行比较。我们保留了美国 14 个州 2001-2015 年间连续参保时间≥7 个月的 18-64 岁男性(N=15,167,636)进行分析。艾滋病毒和 PCa 的诊断是通过非药物索赔确定的。我们估算了按 HIV 感染状况比较的 PCa 特定病因(csHR)发病率,并对年龄、种族-人种、居住州、注册年份和合并症进行了调整,同时按年龄和种族-人种进行了分层。感染 HIV 的男性患 PCa 的风险低于未感染 HIV 的男性(csHR = 0.89;95% CI:0.80,0.99),但因种族族裔而异,在非西班牙裔黑人中观察到的结果相似(csHR = 0.79; 95% CI: 0.69, 0.91)和西班牙裔男性(csHR = 0.85; 95% CI: 0.67, 1.09),但在非西班牙裔白人男性(csHR = 1.17; 95% CI: 0.91, 1.50)中的观察结果相似。在仅限于 50-64 岁和 40-49 岁男性的模型中,研究结果与此类似,但在 18-39 岁男性中却没有发现。根据艾滋病病毒感染状况而报告的 PCa 发病率下降可能仅限于由年龄和种族族裔界定的特定群体。
Incidence of prostate cancer in Medicaid beneficiaries with and without HIV in 2001-2015 in 14 states.
Prostate cancer (PCa) incidence is reportedly lower in men with HIV compared to men without HIV for unknown reasons. We describe PCa incidence by HIV status in Medicaid beneficiaries, allowing for comparison of men with and without HIV who are similar with respect to socioeconomic characteristics and access to healthcare. Men (N = 15,167,636) aged 18-64 with ≥7 months of continuous enrollment during 2001-2015 in 14 US states were retained for analysis. Diagnoses of HIV and PCa were identified using non-drug claims. We estimated cause-specific (csHR) comparing incidence of PCa by HIV status, adjusted for age, race-ethnicity, state of residence, year of enrollment, and comorbid conditions, and stratified by age and race-ethnicity. Hazard of PCa was lower in men with HIV than men without HIV (csHR = 0.89; 95% CI: 0.80, 0.99), but varied by race-ethnicity, with similar observations among non-Hispanic Black (csHR = 0.79; 95% CI: 0.69, 0.91) and Hispanic (csHR = 0.85; 95% CI: 0.67, 1.09), but not non-Hispanic white men (csHR = 1.17; 95% CI: 0.91, 1.50). Findings were similar in models restricted to men aged 50-64 and 40-49, but not in men aged 18-39. Reported deficits in PCa incidence by HIV status may be restricted to specific groups defined by age and race ethnicity.