Improvement of Tamoxifen Induced Foveal Cavitation with Topical Dorzolamide Therapy.

Purpose: To present a case of severe foveal cavitation and near complete macular hole secondary to tamoxifen toxicity that improved after tamoxifen cessation and topical dorzolamide therapy.

Methods: A 45-year-old female referred with bilateral tamoxifen maculopathy. Bilateral foveal cavitation, worse in the right eye (OD) with draping of the internal limiting membrane, was noted with baseline optical coherence tomography.

Results: After discontinuing tamoxifen therapy and administering topical acetazolamide drops, cavitation remarkably improved OD with near resolution of the macular hole, and without recurrence 4 months after discontinuation of the topical drops.

Conclusion: A short course of topical dorzolamide drop therapy may be beneficial in cases with severe foveal cavitation due to tamoxifen toxicity.