利用加压液体萃取大麻(Cannabis sativa L.)中大麻酸的热化学转化动力学。

IF 4.1 Q1 PHARMACOLOGY & PHARMACY Journal of cannabis research Pub Date : 2024-07-30 DOI:10.1186/s42238-024-00243-x
Urvashi, Joon-Hee Han, Min Hong, Tae-Hyung Kwon, Melvin Druelinger, Sang-Hyuck Park, Chad A Kinney, Kenneth J Olejar
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引用次数: 0

摘要

通过热化学转化进行大麻素脱羧具有减少大麻素降解和蒸发的潜力,因为反应时间短,而且使用水作为溶剂。当与加压液体萃取(PLE)相结合时,热化学转化可作为萃取程序的第一阶段进行。加压液体萃取利用温度和压力升高的封闭系统来提高溶解能力,从而降低粘度并提高扩散速度。对于这种新的萃取脱羧方法,在从台式放大到中试或商业规模之前,仍有一些变量需要充分了解。在此,我们研究了工业大麻在不同温度(80-160 °C)和反应时间(1-90 分钟)下通过 PLE 进行热化学脱羧的动力学。研究发现该反应为假一阶反应。对 CBD 和 CBG 的模型验证得出了可接受的结果;然而,次要大麻素的异常表明大麻素浓度可能会影响模型动力学。
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Thermo-chemical conversion kinetics of cannabinoid acids in hemp (Cannabis sativa L.) using pressurized liquid extraction.

Cannabinoid decarboxylation via thermo-chemical conversion has the potential to reduce the cannabinoid degradation and evaporation due to short reaction time and use of water as the solvent. When combined with pressurized liquid extraction (PLE), thermo-chemical conversion can be performed as the first stage in the extraction procedure. PLE utilizes a closed system at elevated temperatures and pressure to increase the solvation power, which contributes to decreased viscosity and increased diffusion rate. With this new in-extraction decarboxylation approach there remain variables that need full understanding before up scaling from bench top to pilot or commercial scale. Herein, the thermo-chemical decarboxylation kinetics was studied for industrial hemp via PLE at different temperatures (80-160 °C) and reaction times (1-90 min). The reaction was found to be pseudo-first order. Model verification on CBD and CBG resulted in acceptable results; however, an anomaly in the minor cannabinoids suggests that cannabinoid concentration may influence model kinetics.

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