研究基于黑木耳的草药成分对原发性甲状腺功能减退症患者的影响:随机对照试验

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI:10.22038/AJP.2024.23984
Najmeh Javidi, Zahra Mazloum Khorasani, Roshanak Salari, Shabnam Niroumand, Mahdi Yousefi
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引用次数: 0

摘要

目的:甲状腺功能减退症的特点是甲状腺分泌的甲状腺素不足。左甲状腺素可能无法完全缓解患者的症状。本研究旨在评估一种草药产品对患者体重、体重指数(BMI)、甲状腺激素、血脂、空腹血糖(FBS)、抑郁和生活质量评分的影响。干预组服用含有Trachyspermum ammi L.、Nigella sativa L.和Citrus aurantifolia L.的草药粉末,对照组服用阿维菌素8周:结果:使用草药产品治疗后,体重指数(BMI)(p=0.03)、臀围(HC)(p=0.008)、腰围(WC)(p)等人体测量变量均有统计学意义的显著降低:结果表明,草药产品对患者的人体测量变量具有潜在的有益影响。此外,干预还明显改善了患者的抑郁症状和生活质量评分。
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Investigation the effect of a herbal composition based on blackseed on patients with primary hypothyroidism: A randomized controlled trial.

Objective: Hypothyroidism is characterized by insufficient production of thyroxine by the thyroid gland. Levothyroxine may not fully alleviate patients' symptoms. This study aimed to assess the impact of a herbal product on weight, body mass index (BMI), thyroid hormones, lipid profile, fasting blood sugar (FBS), depression, and quality-of-life scores in patients.

Materials and methods: 72 patients with primary hypothyroidism, aged between 20 and 65 years old, participated in the trial and they were randomly allocated into two groups. The intervention group received the herbal powder containing Trachyspermum ammi L., Nigella sativa L., and Citrus aurantifolia L. while the control group received Avicel for 8 weeks.

Results: Treatment with the herbal product resulted in statistically significant reductions in anthropometric variables such as BMI (p=0.03), hip circumference (HC) (p=0.008), waist circumference (WC) (p<0.001), and waist-to-hip circumference ratio (WHR) (p=0.003) in the intervention group in comparison between intervention and control groups. However, the decrease in weight was not statistically significant (p=0.08) in the intervention group compared the control group. In comparison between two groups, the depression score exhibited a statistically significant decrease in the intervention (p=0.001) and control groups (p=0.01), while there was a statistically significant increase in the quality-of-life score only in the intervention group (p<0.001) in comparison between intervention and control groups.

Conclusion: The results indicate the potential beneficial effects of the herbal product on anthropometric variables in patients. Furthermore, the intervention yielded significant improvements in depression symptoms and quality-of-life scores among the patients.

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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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