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引用次数: 0
摘要
脂肪组织通过营养交换和分泌脂肪源性荷尔蒙和细胞因子,在全身能量代谢中发挥着核心代谢作用。脂肪组织功能障碍会增加罹患各种疾病的风险,包括 2 型糖尿病、冠状动脉疾病、中风和癌症,最终缩短健康寿命。保持脂肪组织功能作为延长健康寿命的一种手段,最近引起了人们的关注。我们之前开发了一种 T 细胞活化抑制试验,有助于有效筛选出延长健康寿命的候选物质。利用这种检测方法,我们确定了两种候选物质:咖啡中的 N-咖啡酰色氨酸(NCT)。本综述总结了有关 CA 和 NCT 对脂肪细胞(脂肪组织中的初级细胞)功能影响的最新发现,以及它们对延长健康预期寿命的潜在贡献。
[An Investigation of Substances Influencing Adipocyte Function].
Adipose tissue plays a central metabolic role in systemic energy metabolism via nutrient exchange and secretion of adipose-derived hormones and cytokines. Adipose tissue dysfunction increases the risk of developing conditions, including type 2 diabetes, coronary artery disease, stroke, and cancer, ultimately shortening healthy lifespan. Maintaining adipose tissue functions has recently garnered attention as a means to extend healthy life expectancy. We previously developed a T-cell activation-inhibitory assay, which facilitates efficient selection of candidate substances for extending healthy lifespan. Using this assay, we identified two candidate substances: Cynandione A (CA), a major component of Cynanchum wilfordii, and N-caffeoyltryptophan (NCT) found in coffee. This review summarizes recent findings regarding the effect of CA and NCT on adipocyte (the primary cells in adipose tissue) function, and their potential contribution to extending healthy life expectancy.