一例与多发性骨髓瘤复发相关的胸膜和心包淀粉样变性伴有渗出的病例。

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2024-07-31 eCollection Date: 2024-08-01 DOI:10.1002/rcr2.1445
Naoya Ishibashi, Takafumi Sugawara, Yugo Ashino, Ryuga Yabe, Ryo Nonomura, Yutaka Oshima, Takanobu Sasaki
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引用次数: 0

摘要

一名80岁的老人曾患本斯-琼斯波亭(Bence-Jones potein,BJP)λ型多发性骨髓瘤(MM),已缓解16年。之前的一名医生在局部麻醉下进行了胸腔积液检查和胸膜活检,但未能确诊。尽管接受了利尿剂治疗,但他的病情仍需要频繁进行胸腔穿刺。患者被转诊到我院,在全身麻醉下进行的胸腔镜胸膜和心包活检发现了λ型AL淀粉样变性,表明MM复发。尽管对 MM 进行了药物治疗,但患者还是死于吸入性肺炎。该病例强调了在难治性积液的鉴别诊断中考虑淀粉样变性的重要性,尤其是在有 MM 病史的患者中,即使长期缓解后也应考虑淀粉样变性。
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A case of pleural and pericardium amyloidosis with effusion associated with multiple myeloma relapse.

An 80-year-old man with a history of Bence-Jones potein (BJP) λ-type multiple myeloma (MM), which had been in remission for 16 years, was examined for shortness of breath and was found to have bilateral pleural and pericardial effusions. A pleural fluid test and a pleural biopsy under local anaesthesia performed by a previous physician failed to make the diagnosis. Despite diuretic therapy, his condition necessitated frequent thoracentesis. The patient was referred to our hospital and thoracoscopic pleural and pericardial biopsies performed under general anaesthesia revealed λ-type AL amyloidosis, indicating a relapse of MM. Despite drug therapy for MM, the patient died from aspiration pneumonia. The case underscores the importance of considering amyloidosis in differential diagnoses for refractory effusions, especially in patients with a history of MM, even after long-term remission.

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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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