{"title":"放射治疗在鼻窦未分化癌治疗中的作用：基于人群的分析。","authors":"Xin Zhao, Ziqi Pei, Xiang Song, Gang Jin","doi":"10.1002/hed.27862","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.</p><p><strong>Methods: </strong>Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.</p><p><strong>Results: </strong>The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.</p><p><strong>Conclusions: </strong>Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population-based analysis.\",\"authors\":\"Xin Zhao, Ziqi Pei, Xiang Song, Gang Jin\",\"doi\":\"10.1002/hed.27862\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.</p><p><strong>Methods: </strong>Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.</p><p><strong>Results: </strong>The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.</p><p><strong>Conclusions: </strong>Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/hed.27862\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/hed.27862","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
摘要
背景：鼻窦未分化癌（SNUC）是一种罕见的侵袭性疾病，治疗不明确，预后差。本研究旨在评估放射治疗（RT）的作用，并探索最佳治疗顺序：方法：对1973年至2015年间410例SNUC患者的生存趋势进行回顾性分析：结果：在84个月的中位随访中，5年癌症特异性生存率（CSS）为45.1%，总生存率（OS）为38.1%。放疗是改善 CSS 的预后指标（危险比 [HR] = 0.425，95% 置信区间 [CI]：0.299-0.603）：0.299-0.603, p = 0.000）和OS（HR = 0.415, 95% CI: 0.303-0.570, p = 0.000）。然而，在手术和 RT 的联合治疗中，术前和术后 RT（5 年 OS 率分别为 47.1% 和 45.6%，p = 0.486）没有显著差异：结论：放疗在提高SNUC生存率方面发挥着关键作用。结论：放疗在提高SNUC生存率方面发挥着关键作用，术前和术后RT治疗在生存率方面无明显差异。
The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population-based analysis.
Background: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.
Methods: Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.
Results: The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.
Conclusions: Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.
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