Claudia Cardone, Sergio Facchini, Alfonso de Stefano, Anna Maria Rachiglio, Antonio Avallone
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Transient ‘NeoBRAF wild type’ state in a patient with BRAFV600E mutant metastatic colorectal cancer
We report the case of a patient with a BRAFV600E mutant mCRC, with evidence of acquired ‘NeoBRAF wild-type’ (wt) state. The patient, longitudinally assessed by liquid biopsy, obtained a remarkable clinical outcome with a multimodal approach including surgery, systemic treatment and targeted therapy.
In patients with newly diagnosed RAS and BRAFV600E mutant mCRC, longitudinal assessment with liquid biopsy is not routinely used in clinical practice. We report the case of a patient with a BRAFV600E mutant mCRC, with evidence of acquired ‘neoBRAF wild-type’ (wt) state. The patient obtained a remarkable clinical outcome and has been longitudinally assessed by liquid biopsy.
期刊介绍：
The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy.
Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.
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