Synthesis and Study of Sorption Properties of Ca3La6(SiO4)6 Biocomposite for Targeted Delivery of 5-Fluorouracil

Abstract

The dispersed Ca₃La₆(SiO₄)₆ biocomposite was obtained by treating a calcium silicate sol containing 0.1, 0.3, and 0.7 mol of La³⁺ under hydrothermal conditions. The composition, morphology, and structure of the biocomposite were studied by powder X-ray diffraction, SEM, and EDS methods. The reaction products (CaSiO₃, CaLa₄(SiO₄)₃O, Ca₃La₆(SiO₄)₆) depending on the La³⁺ concentration were determined. The structural characteristics of biocomposite powders with different La³⁺ contents were investigated by BET and DFT methods. The sorption characteristics of the materials towards 5-fluorouracil were studied depending on pH. The highest sorption capacity (0.768 mg/g at pH 3) was found for the Ca₃La₆(SiO₄)₆ sample containing 0.3 mol of La³⁺. Additionally, the biocompatible properties of biocomposite samples in contact with artificial blood plasma were evaluated by establishing the key changes in their composition, morphology, and structure upon the formation of the apatite bioactive phase on the accessible surface of the samples. These results hold promise for further development of new sorption materials, including biomaterials, for targeted drug delivery with a potential for practical application.