用于治疗缺铁性贫血的基于聚甲基硅倍半氧烷水凝胶的口腔周围铁化合物输送系统的功能设计

IF 1.8 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR Russian Journal of Inorganic Chemistry Pub Date : 2024-07-31 DOI:10.1134/s0036023624600266

P. D. Orlova, I. B. Meshkov, E. V. Latipov, S. G. Vasil’ev, A. A. Kalinina, A. M. Muzafarov, I. M. Le-Deygen

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引用次数: 0

摘要

摘要提出了一种用于治疗缺铁性贫血的口服铁药物输送系统的开发方法。这种新系统以具有可变结构的聚甲基硅倍半氧烷水凝胶为生物相容性和可生物降解的支持物。研究发现，这种水凝胶对饱和的氯化铁-6H2O（0.27 M）溶液具有很高的吸附能力，而对饱和的葡萄糖酸铁（0.24 M）溶液的吸附能力较低，仅为 30%左右。通过红外光谱和紫外光谱研究了所开发的递送系统，并研究了铁原子在水凝胶上的分布。研究发现，所制备的系统有望用于药物制剂的进一步开发。

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Functional Design of Peroral Iron Compound Delivery Systems Based on Polymethylsilsesquioxane Hydrogels for the Therapy of Iron Deficiency Anemia

Abstract

An approach to the development of peroral iron drug delivery systems for the therapy of iron deficiency anemia is proposed. The new systems are based on polymethylsilsesquioxane hydrogels with a variable structure as biocompatible and biodegradable supports. The hydrogels are found to exhibit a high sorption capacity toward a saturated solution of FeCl₃∙6H₂O (0.27 M), whereas the sorption capacity toward a saturated solution of iron D-gluconate (0.24 M) is lower and amounts to ~30%. The developed delivery systems are studied by IR and UV spectroscopy, and the iron atom distribution over the hydrogels is studied. The prepared systems are found to be promising for the further development of drug formulations.

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来源期刊

Russian Journal of Inorganic Chemistry 化学-无机化学与核化学

CiteScore

3.10

自引率

38.10%

发文量

237

审稿时长

3 months

期刊介绍： Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.