Design and Synthesis of Novel 1,4-Dihydropyridine Derivatives as Antioxidant and Antimicrobial Agents

Abstract

1,4 Dihydropyridines are one of the most used scaffolds in drug development. The present paper describes the autocatalytic four-component reactions of heterocyclic aldehydes, malononitrile, and piperidine, leading to novel 2-amino-1,4-dihydro-6-[pyridin-1(4H)-yl]-4-(hetero-2/3-yl)pyridine-3,5-dicarbonitrile derivatives in good yields. The structure of the synthesized compounds was confirmed by IR and ¹H and ¹³C NMR and mass spectrometry. 4-(1H-Indol-3-yl)-substituted 1,4-dihydropyridine exhibited good radical scavenging activity, while its thiophen-2-yl-substituted analog proved to be potent antimicrobial agent.