Ola Abdalsalam, Scott Howard, Thomas D. O’Sullivan
{"title":"基于相位的结构化询问频域近红外光谱仪","authors":"Ola Abdalsalam, Scott Howard, Thomas D. O’Sullivan","doi":"10.1364/josaa.523194","DOIUrl":null,"url":null,"abstract":"Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error. Particularly noteworthy, the phase-only component of SI FD-NIRS can quantify both the optical absorption and reduced scattering in homogeneous tissues and shows a 20% improved sensitivity to absorption changes in deeper tissues compared to conventional methods. We show that this enhanced sensitivity is promising for improving the accuracy of functional brain monitoring in the cortex of an infant with less superficial contamination.","PeriodicalId":501620,"journal":{"name":"Journal of the Optical Society of America A","volume":"50 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phase-based structured interrogation frequency-domain near-infrared spectroscopy\",\"authors\":\"Ola Abdalsalam, Scott Howard, Thomas D. O’Sullivan\",\"doi\":\"10.1364/josaa.523194\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error. Particularly noteworthy, the phase-only component of SI FD-NIRS can quantify both the optical absorption and reduced scattering in homogeneous tissues and shows a 20% improved sensitivity to absorption changes in deeper tissues compared to conventional methods. We show that this enhanced sensitivity is promising for improving the accuracy of functional brain monitoring in the cortex of an infant with less superficial contamination.\",\"PeriodicalId\":501620,\"journal\":{\"name\":\"Journal of the Optical Society of America A\",\"volume\":\"50 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Optical Society of America A\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1364/josaa.523194\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Optical Society of America A","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/josaa.523194","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error. Particularly noteworthy, the phase-only component of SI FD-NIRS can quantify both the optical absorption and reduced scattering in homogeneous tissues and shows a 20% improved sensitivity to absorption changes in deeper tissues compared to conventional methods. We show that this enhanced sensitivity is promising for improving the accuracy of functional brain monitoring in the cortex of an infant with less superficial contamination.