使用同型半胱氨酸修饰的金纳米粒子对无机砷 (iAsIII) 进行选择性比色检测

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-29 DOI:10.1002/jccs.202400133
Wei-Bin Tseng, Chien-Er Huang, Huan-Tsung Chang
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引用次数: 0

摘要

环境水体中的砷污染给全球健康和环境带来了风险。本研究解决了快速、选择性和灵敏检测环境样本中无机砷(iAsIII)的迫切需求。利用金纳米粒子(AuNPs)的独特性质和同型半胱氨酸(Hcy)的选择性结合亲和力,我们开发了一种新型比色传感器来检测 iAsIII。我们的研究阐明了 Hcy 修饰 AuNPs 的机理,通过胺和羧基之间的螯合作用实现了对 iAsIII 离子的选择性检测,在 pH 值为 12.0 时主要检测 H2AsO3-。我们的传感器在环境样品中常见的各种干扰离子中实现了对 iAsIII 的高选择性(10 倍)。此外,我们的 iAsIII 检测灵敏度极高,检测限(LOD)低至 67 nM,符合饮用水中砷浓度的监管标准。通过对各种金属离子和真实水样的实验,我们验证了传感器的选择性和灵敏度。总之,我们的研究全面了解了 Hcy 修饰的 AuNPs 检测 iAsIII 的机制、选择性和灵敏度,为环境监测和公共卫生提供了一个多功能纳米传感器平台,具有重要意义。
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Selective colorimetric detection of inorganic arsenic (iAsIII) using homocysteine-modified gold nanoparticles

Arsenic contamination in environmental waters poses global health and environmental risks. This study addresses the urgent need for rapid, selective, and sensitive detection of inorganic arsenic (iAsIII) in environmental samples. Leveraging the unique properties of gold nanoparticles (AuNPs) and the selective binding affinity of homocysteine (Hcy), we developed a novel colorimetric sensor for iAsIII detection. Our investigation elucidates the mechanism by which Hcy modifies AuNPs, enabling the selective detection of iAsIII ions through chelation between amine and carboxyl groups, primarily with the predominant species H2AsO3 at pH 12.0. Our sensor achieves high selectivity (>10-fold) for iAsIII amid various interfering ions commonly found in environmental samples. Furthermore, we demonstrate exceptional sensitivity in detecting iAsIII, with a low limit of detection (LOD) of 67 nM, aligning with regulatory standards for arsenic concentration in drinking water. The selectivity and sensitivity of our sensor were validated through experiments with various metal ions and real water samples. In conclusion, our study presents a comprehensive understanding of the mechanism, selectivity, and sensitivity of Hcy-modified AuNPs in detecting iAsIII, offering a versatile nanosensor platform with significant implications for environmental monitoring and public health.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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