Francesca Porto, Sara Cisternino, Emiliano Cazzola, Giorgia Speltri, Liliana Mou, Alessandra Boschi, Lorenza Marvelli, Giovanni Di Domenico, Antonella Pagnoni, Lucia De Dominicis, Irene Calliari, Claudio Gennari, Licia Uccelli, Gaia Pupillo, Giancarlo Gorgoni, Juan Esposito, Petra Martini
{"title":"回旋加速器生产锰-52：多模态 PET/MRI 成像的前景广阔的途径。","authors":"Francesca Porto, Sara Cisternino, Emiliano Cazzola, Giorgia Speltri, Liliana Mou, Alessandra Boschi, Lorenza Marvelli, Giovanni Di Domenico, Antonella Pagnoni, Lucia De Dominicis, Irene Calliari, Claudio Gennari, Licia Uccelli, Gaia Pupillo, Giancarlo Gorgoni, Juan Esposito, Petra Martini","doi":"10.1186/s41181-024-00288-6","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of <sup>52</sup>Mn for PET/MRI imaging.</p><h3>Results</h3><p>Using the <sup>52</sup>Cr(p,n)<sup>52</sup>Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating <sup>52</sup>Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality <sup>52</sup>Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.</p><h3>Conclusions</h3><p>The developed technology offers a promising avenue for producing <sup>52</sup>Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.</p></div>","PeriodicalId":534,"journal":{"name":"EJNMMI Radiopharmacy and Chemistry","volume":"9 1","pages":""},"PeriodicalIF":4.4000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297007/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging\",\"authors\":\"Francesca Porto, Sara Cisternino, Emiliano Cazzola, Giorgia Speltri, Liliana Mou, Alessandra Boschi, Lorenza Marvelli, Giovanni Di Domenico, Antonella Pagnoni, Lucia De Dominicis, Irene Calliari, Claudio Gennari, Licia Uccelli, Gaia Pupillo, Giancarlo Gorgoni, Juan Esposito, Petra Martini\",\"doi\":\"10.1186/s41181-024-00288-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of <sup>52</sup>Mn for PET/MRI imaging.</p><h3>Results</h3><p>Using the <sup>52</sup>Cr(p,n)<sup>52</sup>Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating <sup>52</sup>Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality <sup>52</sup>Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.</p><h3>Conclusions</h3><p>The developed technology offers a promising avenue for producing <sup>52</sup>Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.</p></div>\",\"PeriodicalId\":534,\"journal\":{\"name\":\"EJNMMI Radiopharmacy and Chemistry\",\"volume\":\"9 1\",\"pages\":\"\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297007/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJNMMI Radiopharmacy and Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s41181-024-00288-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJNMMI Radiopharmacy and Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1186/s41181-024-00288-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging
Background
The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of 52Mn for PET/MRI imaging.
Results
Using the 52Cr(p,n)52Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating 52Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality 52Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.
Conclusions
The developed technology offers a promising avenue for producing 52Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.
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