细胞外基质重塑与癌症治疗之间的相互作用

IF 29.7 1区 医学 Q1 ONCOLOGY Cancer discovery Pub Date : 2024-08-02 DOI:10.1158/2159-8290.CD-24-0002
Jai Prakash, Yuval Shaked
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引用次数: 0

摘要

细胞外基质(ECM)是大多数实体瘤中的一种丰富的非细胞成分,已知它支持肿瘤的进展和转移。ECM 与癌症疗法之间的相互作用为了解癌症生物学开辟了新的途径。众所周知,ECM 可作为生物力学屏障保护肿瘤免受抗癌药物的侵袭,但新的研究表明,各种癌症疗法会诱导 ECM 重塑,从而导致耐药性和肿瘤进展。本综述讨论了这一领域的关键问题,包括 ECM 如何影响治疗结果、癌症疗法如何影响 ECM 重塑以及与靶向 ECM 相关的挑战。重要意义:细胞外基质 (ECM) 与癌症疗法之间错综复杂的关系揭示了肿瘤生物学及其有效治疗的新见解。虽然 ECM 可保护肿瘤免受抗癌药物的侵袭,但最近的研究强调了治疗诱导的 ECM 重塑在促进治疗耐药性和肿瘤进展方面的矛盾作用。本综述探讨了 ECM 与癌症疗法之间相互作用的关键方面。
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The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics.

The extracellular matrix (ECM) is an abundant noncellular component of most solid tumors known to support tumor progression and metastasis. The interplay between the ECM and cancer therapeutics opens up new avenues in understanding cancer biology. While the ECM is known to protect the tumor from anticancer agents by serving as a biomechanical barrier, emerging studies show that various cancer therapies induce ECM remodeling, resulting in therapy resistance and tumor progression. This review discusses critical issues in this field including how the ECM influences treatment outcome, how cancer therapies affect ECM remodeling, and the challenges associated with targeting the ECM. Significance: The intricate relationship between the extracellular matrix (ECM) and cancer therapeutics reveals novel insights into tumor biology and its effective treatment. While the ECM may protect tumors from anti-cancer agents, recent research highlights the paradoxical role of therapy-induced ECM remodeling in promoting treatment resistance and tumor progression. This review explores the key aspects of the interplay between ECM and cancer therapeutics.

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来源期刊
Cancer discovery
Cancer discovery ONCOLOGY-
CiteScore
22.90
自引率
1.40%
发文量
838
审稿时长
6-12 weeks
期刊介绍: Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.
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