阿司匹林对肩袖撕裂大鼠模型的生物力学和组织学评估

IF 1.6 4区 医学 Journal of Orthopaedic Surgery Pub Date : 2024-05-01 DOI:10.1177/10225536241265827
Seok Won Chung, Seung Ho Chung, Dong-Hyun Kim, Hyun Joo Lee, Eugene J Park, Bum-Jin Shim, Chul-Hyun Cho, Jong Pil Yoon
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引用次数: 0

摘要

背景:阿司匹林是一种具有代表性的非甾体抗炎药(NSAIDs),临床上常用于治疗肌腱病。本研究旨在评估阿司匹林对肩袖撕裂修复后肌腱与骨界面愈合的生物力学和组织学影响。研究方法将 20 只雄性 Sprague-Dawley 大鼠随机分为两组,每组 10 只。C组在肌腱修复后进行修复,A组在肌腱修复后使用阿司匹林治疗。阿司匹林组大鼠腹腔注射阿司匹林,每24小时一次,每次10毫克/千克,连续7天。术后八周,对每只大鼠的左肩进行组织学分析,右肩进行生物力学分析。结果在生物力学分析中,载荷-破坏(C 组:0.61 ± 0.32 N,阿司匹林组:0.74 ± 0.91 N;p = .697)和极限应力(C 组:0.05 ± 0.01 MPa,阿司匹林组:0.29 ± 0.43 MPa;p = .095)无显著差异。在伸长率方面(C 组:222.62 ± 57.98%,阿司匹林组:194.75 ± 75.16%;p = .028),阿司匹林组的伸长率低于 C 组。在组织学评估中,Bonar 评分证实两组之间在胶原纤维密度(C 组:1.60 ± 0.52,阿司匹林组:2.60 ± 0.52,p = .001)和血管性(C 组:1.00 ± 0.47,阿司匹林组:2.20 ± 0.63,p = .001)方面存在显著差异。结论肩袖撕裂修复术后注射阿司匹林可增强肌腱愈合早期重塑阶段的愈合效果。
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Biomechanical and histological evaluation of aspirin in rotator cuff tear rat model.

Background: Aspirin is a representative non-steroidal anti-inflammatory drug (NSAIDs) and has been commonly used for the treatment of tendinopathy in clinical practice. In this study, we aimed to evaluate the biomechanical and histological healing effects of aspirin on the healing of the tendon-to-bone interface after rotator cuff tear repair. Methods: A total of 20 male Sprague-Dawley rats were randomly divided into two groups of 10 rats each. Group-C performed repaironly, and group-aspirin treated with aspirin after tendon repair. Group-aspirin rat were intraperitoneally injected with aspirin at 10 mg/kg every 24 h for 7 days. Eight weeks after surgery, the left shoulder of each rat was used for histological analysis and the right shoulder for biomechanical analysis. Results: In the biomechanical analysis, there was no significant difference in load-to-failure (group-C: 0.61 ± 0.32 N, group-aspirin: 0.74 ± 0.91 N; p = .697) and ultimate stress (group-C: 0.05 ± 0.01 MPa, group-aspirin: 0.29 ± 0.43 MPa; p = .095). For the elongation (group-C: 222.62 ± 57.98%, group-aspirin: 194.75 ± 75.16%; p = .028), group-aspirin confirmed a lower elongation level than group-C. In the histological evaluation, the Bonar score confirmed significant differences in collagen fiber density (group-C: 1.60 ± 0.52, group-aspirin: 2.60 ± 0.52, p = .001) and vascularity (group-C: 1.00 ± 0.47, group-aspirin: 2.20 ± 0.63, p = .001) between the groups. Conclusions: Aspirin injection after rotator cuff tear repair may enhance the healing effect during the early remodeling phase of tendon healing.

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期刊介绍: Journal of Orthopaedic Surgery is an open access peer-reviewed journal publishing original reviews and research articles on all aspects of orthopaedic surgery. It is the official journal of the Asia Pacific Orthopaedic Association. The journal welcomes and will publish materials of a diverse nature, from basic science research to clinical trials and surgical techniques. The journal encourages contributions from all parts of the world, but special emphasis is given to research of particular relevance to the Asia Pacific region.
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