墨西哥高活性多发性硬化症患者使用克拉利宾的早期临床效果。

IF 2.5 Q2 CLINICAL NEUROLOGY Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-08-01 eCollection Date: 2024-07-01 DOI:10.1177/20552173241260156
Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa
{"title":"墨西哥高活性多发性硬化症患者使用克拉利宾的早期临床效果。","authors":"Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa","doi":"10.1177/20552173241260156","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.</p><p><strong>Objective: </strong>Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.</p><p><strong>Method: </strong>A multicenter cohort study analyzed retrospective data from individuals with \"highly active\" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.</p><p><strong>Results: </strong>In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (<i>p</i> = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292702/pdf/","citationCount":"0","resultStr":"{\"title\":\"Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.\",\"authors\":\"Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa\",\"doi\":\"10.1177/20552173241260156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.</p><p><strong>Objective: </strong>Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.</p><p><strong>Method: </strong>A multicenter cohort study analyzed retrospective data from individuals with \\\"highly active\\\" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.</p><p><strong>Results: </strong>In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (<i>p</i> = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.</p>\",\"PeriodicalId\":18961,\"journal\":{\"name\":\"Multiple Sclerosis Journal - Experimental, Translational and Clinical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292702/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple Sclerosis Journal - Experimental, Translational and Clinical\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/20552173241260156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20552173241260156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:克拉利宾对多发性硬化症(MS)具有疗效,但拉丁美洲(LATAM)的实际数据有限:克拉利宾对多发性硬化症(MS)有疗效,但拉丁美洲(LATAM)的实际数据有限,尽管存在潜在的社会人口学差异:调查墨西哥高活性多发性硬化症患者的基线特征和临床反应,确定早期治疗反应的预测因素:一项多中心队列研究分析了墨西哥 11 家诊所的克拉德瑞滨患者支持计划中 "高度活跃 "多发性硬化症患者的回顾性数据。标准包括曾接受另一种疾病改变疗法治疗一年,以及近期复发并有特定磁共振成像结果。主要结果集中在 12 个月后达到 NEDA-3 状态:在随访中,67.5%的患者保持了NEDA-3状态。基线EDSS评分从1.50显著下降至1.00(p = 0.011),无确诊残疾恶化。在人口统计学和临床变量方面,NEDA-3达标者与未达标者无明显差异。无严重不良反应报告:结论:克拉利宾可早期有效控制墨西哥活动性多发性硬化症患者的病情,其安全性和不良反应极低。这项研究为拉丁美洲和加勒比海地区提供了宝贵的实际证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.

Background: Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.

Objective: Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.

Method: A multicenter cohort study analyzed retrospective data from individuals with "highly active" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.

Results: In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (p = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.

Conclusion: Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
期刊最新文献
Cannabinoids for spasticity in patients with multiple sclerosis: A systematic review and meta-analysis. Treatment effect modifiers of immunotherapies for relapsing-remitting multiple sclerosis-A systematic review and meta-analysis. Cesarian sections in women with multiple sclerosis: A Canadian prospective pregnancy study. Exploring the relationship between neurologists and older persons with multiple sclerosis through the lens of social support theory. Illness representation in patients with multiple sclerosis: A preliminary narrative medicine study.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1