Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa
{"title":"墨西哥高活性多发性硬化症患者使用克拉利宾的早期临床效果。","authors":"Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa","doi":"10.1177/20552173241260156","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.</p><p><strong>Objective: </strong>Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.</p><p><strong>Method: </strong>A multicenter cohort study analyzed retrospective data from individuals with \"highly active\" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.</p><p><strong>Results: </strong>In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (<i>p</i> = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.</p>","PeriodicalId":18961,"journal":{"name":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292702/pdf/","citationCount":"0","resultStr":"{\"title\":\"Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.\",\"authors\":\"Sergio Sauri-Suarez, Sandra Quiñones, Manuel De la Maza-Flores, Arturo Marin-Contreras, Gil Playas-Pérez, Brenda Bertado-Cortes, Francisco Frias-Marquez, Gilberto Zuñiga-García, Francisco Rodriguez-Leal, Carlos Blaisdell-Vidal, Enrique Gomez-Figueroa\",\"doi\":\"10.1177/20552173241260156\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.</p><p><strong>Objective: </strong>Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.</p><p><strong>Method: </strong>A multicenter cohort study analyzed retrospective data from individuals with \\\"highly active\\\" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.</p><p><strong>Results: </strong>In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (<i>p</i> = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.</p>\",\"PeriodicalId\":18961,\"journal\":{\"name\":\"Multiple Sclerosis Journal - Experimental, Translational and Clinical\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292702/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple Sclerosis Journal - Experimental, Translational and Clinical\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/20552173241260156\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/7/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal - Experimental, Translational and Clinical","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20552173241260156","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Early clinical effect of cladribine in patients with highly active multiple sclerosis in Mexico.
Background: Cladribine shows efficacy in multiple sclerosis (MS), but Latin American (LATAM) real-world data is limited, despite potential sociodemographic variations.
Objective: Investigate baseline characteristics and clinical response in highly active MS patients in Mexico, identifying predictors of early treatment response.
Method: A multicenter cohort study analyzed retrospective data from individuals with "highly active" MS in the Cladribine Patient Support Program across 11 Mexican clinics. Criteria included one-year prior treatment with another disease-modifying treatment and recent relapse with specific MRI findings. Primary outcomes focused on achieving NEDA-3 status after 12 months.
Results: In the follow-up, 67.5% maintained NEDA-3 status. Baseline EDSS scores decreased significantly from 1.50 to 1.00 (p = 0.011), with no confirmed disability worsening. No significant differences were observed between NEDA-3 achievers and non-achievers in demographic and clinical variables. No severe adverse events were reported.
Conclusion: Cladribine showed early and effective control of active MS in Mexican patients, demonstrating a secure profile with minimal adverse events. This study provides valuable real-world evidence in the LATAM context.