{"title":"吸入药物治疗对慢性阻塞性肺病炎症因子和生活质量的影响。","authors":"Guang-Ming Dai, Hong Wang","doi":"10.12669/pjms.40.7.7106","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of inhaled triple therapy in the treatment of stable chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>This is a clinical comparative study. A total of 80 patients with COPD admitted to the First People's Hospital of Suining City from June 2020 to June 2023 were included and randomly divided into the study (conventional COPD treatment + inhaled triple therapy) and control (conventional COPD treatment) groups. The clinical efficacy of inhaled triple therapy and adverse reactions of the two groups to the treatment were observed. Clinical efficacy was assessed through changes in pulmonary function indexes, and comparisons of T lymphocyte subsets and serum inflammatory markers were conducted. In addition, St George's Respiratory Questionnaire (SGRQ) was employed for the quality-of-life assessment.</p><p><strong>Results: </strong>The study group showed a significantly higher total efficacy than the control group (<i>P</i> < 0.05), with no significant difference in terms of adverse reactions between them (<i>P</i> > 0.05). After treatment, the study group showed better improvement in pulmonary function indexes, such as forced expiratory volume in one second (FEV<sub>1</sub>), FEV<sub>1</sub> as a percentage of the expected value, forced vital capacity (FVC) and FEV<sub>1</sub>/FVC, compared with the control group (all <i>P</i> < 0.05). In addition, the study group presented higher levels of T lymphocyte subsets CD3<sup>+</sup>, CD4<sup>+</sup> and CD4<sup>+</sup>/CD8<sup>+</sup> than the control group(all <i>P</i> < 0.05). After treatment, the levels of inflammatory markers tumour necrosis factor-α, leukotriene B4 LTB4 and interleukin-6 in the study group decreased more than those in the control group (all <i>P</i> < 0.05). Moreover, the study group attained a lower SGRQ score than the control group (all <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Triple inhalants further improve the clinical efficacy of the treatment of COPD.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11255791/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of inhalation drug therapy on inflammatory factors and quality of life on stable chronic obstructive pulmonary disease.\",\"authors\":\"Guang-Ming Dai, Hong Wang\",\"doi\":\"10.12669/pjms.40.7.7106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the clinical efficacy of inhaled triple therapy in the treatment of stable chronic obstructive pulmonary disease (COPD).</p><p><strong>Methods: </strong>This is a clinical comparative study. A total of 80 patients with COPD admitted to the First People's Hospital of Suining City from June 2020 to June 2023 were included and randomly divided into the study (conventional COPD treatment + inhaled triple therapy) and control (conventional COPD treatment) groups. The clinical efficacy of inhaled triple therapy and adverse reactions of the two groups to the treatment were observed. Clinical efficacy was assessed through changes in pulmonary function indexes, and comparisons of T lymphocyte subsets and serum inflammatory markers were conducted. In addition, St George's Respiratory Questionnaire (SGRQ) was employed for the quality-of-life assessment.</p><p><strong>Results: </strong>The study group showed a significantly higher total efficacy than the control group (<i>P</i> < 0.05), with no significant difference in terms of adverse reactions between them (<i>P</i> > 0.05). After treatment, the study group showed better improvement in pulmonary function indexes, such as forced expiratory volume in one second (FEV<sub>1</sub>), FEV<sub>1</sub> as a percentage of the expected value, forced vital capacity (FVC) and FEV<sub>1</sub>/FVC, compared with the control group (all <i>P</i> < 0.05). In addition, the study group presented higher levels of T lymphocyte subsets CD3<sup>+</sup>, CD4<sup>+</sup> and CD4<sup>+</sup>/CD8<sup>+</sup> than the control group(all <i>P</i> < 0.05). After treatment, the levels of inflammatory markers tumour necrosis factor-α, leukotriene B4 LTB4 and interleukin-6 in the study group decreased more than those in the control group (all <i>P</i> < 0.05). 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引用次数: 0
摘要
目的探讨吸入三联疗法在治疗稳定期慢性阻塞性肺病(COPD)中的临床疗效:方法:这是一项临床对比研究。纳入 2020 年 6 月至 2023 年 6 月遂宁市第一人民医院收治的 COPD 患者共 80 例,随机分为研究组(常规 COPD 治疗 + 吸入式三联疗法)和对照组(常规 COPD 治疗)。观察两组患者吸入三联疗法的临床疗效及治疗后的不良反应。临床疗效通过肺功能指标的变化进行评估,并对 T 淋巴细胞亚群和血清炎症标志物进行比较。此外,还采用了圣乔治呼吸问卷(SGRQ)进行生活质量评估:研究组的总有效率明显高于对照组(P < 0.05),不良反应方面无明显差异(P > 0.05)。治疗后,与对照组相比,研究组的肺功能指标,如一秒钟用力呼气容积(FEV1)、FEV1 占预期值的百分比、用力肺活量(FVC)和 FEV1/FVC 均有更好的改善(均 P <0.05)。此外,与对照组相比,研究组的 T 淋巴细胞亚群 CD3+、CD4+ 和 CD4+/CD8+ 水平更高(均为 P <0.05)。治疗后,研究组的炎症标志物肿瘤坏死因子-α、白三烯 B4 LTB4 和白细胞介素-6 水平的下降幅度高于对照组(均为 P <0.05)。此外,研究组的 SGRQ 评分也低于对照组(所有 P <0.05):结论:三联吸入剂能进一步提高慢性阻塞性肺疾病的临床疗效。
Effect of inhalation drug therapy on inflammatory factors and quality of life on stable chronic obstructive pulmonary disease.
Objective: To investigate the clinical efficacy of inhaled triple therapy in the treatment of stable chronic obstructive pulmonary disease (COPD).
Methods: This is a clinical comparative study. A total of 80 patients with COPD admitted to the First People's Hospital of Suining City from June 2020 to June 2023 were included and randomly divided into the study (conventional COPD treatment + inhaled triple therapy) and control (conventional COPD treatment) groups. The clinical efficacy of inhaled triple therapy and adverse reactions of the two groups to the treatment were observed. Clinical efficacy was assessed through changes in pulmonary function indexes, and comparisons of T lymphocyte subsets and serum inflammatory markers were conducted. In addition, St George's Respiratory Questionnaire (SGRQ) was employed for the quality-of-life assessment.
Results: The study group showed a significantly higher total efficacy than the control group (P < 0.05), with no significant difference in terms of adverse reactions between them (P > 0.05). After treatment, the study group showed better improvement in pulmonary function indexes, such as forced expiratory volume in one second (FEV1), FEV1 as a percentage of the expected value, forced vital capacity (FVC) and FEV1/FVC, compared with the control group (all P < 0.05). In addition, the study group presented higher levels of T lymphocyte subsets CD3+, CD4+ and CD4+/CD8+ than the control group(all P < 0.05). After treatment, the levels of inflammatory markers tumour necrosis factor-α, leukotriene B4 LTB4 and interleukin-6 in the study group decreased more than those in the control group (all P < 0.05). Moreover, the study group attained a lower SGRQ score than the control group (all P < 0.05).
Conclusion: Triple inhalants further improve the clinical efficacy of the treatment of COPD.
期刊介绍:
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.