探索因果联系:从全基因组测序数据库了解糖尿病肾病和肠道微生物群。

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI:10.1080/0886022X.2024.2385065
Rui Lin, Rongping Chen
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引用次数: 0

摘要

近年来,随着生活水平的提高,糖尿病的发病率也在不断上升。糖尿病肾病(DN)作为糖尿病的一种常见并发症,其发病率也在不断上升。虽然一些临床研究和综述暗示糖尿病肾病与肠道微生物群(GM)之间存在联系,但这种联系的性质,特别是其致病性,仍不确定。调查糖尿病肾病与肠道微生物群之间的因果关系有望帮助疾病筛查和确定新的生物标志物。在这项研究中,我们采用了双样本孟德尔随机分析法。我们的数据集包括来自 GWAS 数据库的 4111 名 DN 患者,以及组成对照组的 308539 名患者。我们的目的是在已知的 211 种肠道微生物群类型中,找出可能与糖尿病肾病有直接因果关系的特定类别。我们采取了严格的措施,包括广泛的异质性和敏感性分析,以减轻混杂变量对实验结果的影响。最终,我们的综合分析揭示了 15 个不同类别的肠道微生物群与糖尿病肾病的因果关系。总之,类杆菌科(Bacteroidota)和疣状芽胞杆菌科(Verrucomicrobiae)、Peptostreptococcaceae 和 Veillonellaceae 科、Akkermansia 属、Catenibacterium、Lachnoclostridium、Parasutterella 种、类杆菌目(Bacteroidales)和疣状芽胞杆菌目(Verrucomicrobiales)以及类杆菌科(Bacteroidetes)被确定为增加糖尿病肾病风险的相关因素。相反,Victivallaceae 科、Eubacterium coprostanoligenes 菌种和严格意义上的梭状芽孢杆菌 1 组则被认为与 DN 的发生具有保护作用。这些发现不仅提供了有价值的见解,还为临床研究开辟了新的途径,为潜在的治疗方法提供了新的方向。
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Exploring the causal connection: insights into diabetic nephropathy and gut microbiota from whole-genome sequencing databases.

Over recent years, the prevalence of diabetes has been on the rise, paralleling improvements in living standards. Diabetic nephropathy (DN), a prevalent complication of diabetes, has also exhibited a growing incidence. While some clinical studies and reviews have hinted at a link between diabetic nephropathy and gut microbiota (GM), the nature of this connection, specifically its causative nature, remains uncertain. Investigating the causal relationship between diabetic nephropathy and gut microbiota holds the promise of aiding in disease screening and identifying novel biomarkers. In this study, we employed a two-sample Mendelian randomization analysis. Our dataset encompassed 4,111 DN patients from the GWAS database, juxtaposed with 308,539 members forming a control group. The aim was to pinpoint specific categories within the vast spectrum of the 211 known gut microbiota types that may have a direct causal relationship with diabetic nephropathy. Rigorous measures, including extensive heterogeneity and sensitivity analyses, were implemented to mitigate the influence of confounding variables on our experimental outcomes. Ultimately, our comprehensive analysis revealed 15 distinct categories of gut microbiota that exhibit a causal association with diabetic nephropathy. In summary, the phyla Bacteroidota and Verrucomicrobiae, the families Peptostreptococcaceae and Veillonellaceae, the genus Akkermansia, and the species Catenibacterium, Lachnoclostridium, Parasutterella, along with the orders Bacteroidales and Verrucomicrobiales, and the class Bacteroidetes were identified as correlates of increased risk for DN. Conversely, the family Victivallaceae, the species Eubacterium coprostanoligenes, and the Clostridium sensu stricto 1 group were found to be associated with a protective effect against the development of DN.These findings not only provide valuable insights but also open up novel avenues for clinical research, offering fresh directions for potential treatments.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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