评估在三个不同部位注射肉毒杆菌毒素 A 治疗早泄的有效性和安全性。

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urologia Journal Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI:10.1177/03915603241265825
Ahmed Rashad Elshahid, Abobakr Osama Abdel-Goad Taher, Ahmed Hassan Nouh
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引用次数: 0

摘要

背景:早泄(PE)是一种常见的性问题,会对患者和伴侣的生活质量造成不良影响。通过注射肉毒杆菌毒素-A抑制射精阶段的肌肉收缩,可以延缓射精:本研究旨在评估肉毒杆菌毒素A注射液治疗PE的有效性和安全性:本研究包括45名被诊断为原发性PE的已婚男性患者。所有患者均在三个部位(阴茎根部(第 1 组)、阴茎龟头(第 2 组)和阴茎海绵体肌两侧(第 3 组))注射了 75 单位 Dysport 和 25 单位肉毒杆菌毒素 A(Botox)。所有患者在治疗前后均使用秒表评估阴道内射精潜伏时间(IELT),并回答早泄诊断工具(PEDT)问卷:各组治疗后的射精延迟时间均有明显改善。第 3 组的改善最为明显(平均提高 108%),其次分别是第 1 组(74%)和第 2 组(40%)。年龄与 IELT 的改善呈正相关。第一组和第三组的 PEDTq 评分在统计学上有明显改善:结论:在阴茎根部和阴茎海绵体肌注射肉毒杆菌毒素 A 可用于治疗早泄。
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Evaluation of efficacy and safety of Botulinum toxin-A injection at three deferent sites in treatment of premature ejaculation.

Background: Premature ejaculation (PE) is a common sexual problem, resulting in adverse effects on the quality of life, of both the patient and the partner. The idea of muscular contraction inhibition during the ejection phase of ejaculation by Botulinum toxin-A injection may delay ejaculation.

Aim of study: This study was performed to assess the efficacy and safety of Botulinum toxin-A injection in PE treatment.

Material and methods: This study included 45 married male patients diagnosed with primary PE. All included patients were injected with 75 units of Dysport equal efficacy of 25 units of Botulinum toxin-A (Botox) into three sites: the root of the penis (Group 1), glans penis (Group 2), and each side of the ischiocavernosus muscle (Group 3). All patients were subjected to an assessment of intravaginal ejaculation latency time (IELT) using a stopwatch and answering the Premature Ejaculation Diagnostic Tool (PEDT) Questionnaire before and after treatment.

Results: There was a statistically significant improvement in IELT after treatment in all groups. The most significant improvement was shown in Group 3 (average 108% increase), followed by Group 1 (74%) and Group 2 (40%), respectively. There was a positive correlation between age and the improvement in improved IELT. There was a statistically significant improvement in PEDTq scores in Group 1 and Group 3.

Conclusion: Botulinum toxin-A injection into the root of the penis and ischiocavernosus muscle could be recommended in the treatment of premature ejaculation.

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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
期刊最新文献
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