谁需要长效注射抗逆转录病毒疗法?佛罗里达州成年 HIV 感染者的治疗偏好。

IF 1.2 4区 医学 Q4 HEALTH POLICY & SERVICES Aids Care-Psychological and Socio-Medical Aspects of Aids/hiv Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI:10.1080/09540121.2024.2383872
Rebecca J Fisk-Hoffman, Yiyang Liu, Charurut Somboonwit, Maya Widmeyer, Shantrel Canidate, Mattia Prosperi, Robert L Cook
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引用次数: 0

摘要

艾滋病病毒感染者(PWH)可以选择长效注射抗逆转录病毒疗法(ART),但哪些艾滋病病毒感染者更愿意选择这种疗法尚不清楚。本研究采用安德森行为模型(Andersen Behavioral Model)确定了更倾向于接受 LAI 抗逆转录病毒疗法的艾滋病感染者的特征。佛罗里达队列(Florida Cohort)从社区诊所招募了成年艾滋病感染者,该队列的横截面数据包含了艾滋病感染者的倾向性(人口统计学)、有利条件(交通、收入)和需求(坚持抗逆转录病毒疗法)等信息。
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Who wants long-Acting injectable antiretroviral therapy? Treatment preferences among adults with HIV in Florida.

Long-acting injectable (LAI) antiretroviral therapy (ART) is available to people with HIV (PWH), but it is unknown which PWH prefer this option. Using the Andersen Behavioral Model this study identifies characteristics of PWH with greater preference for LAI ART. Cross-sectional data from the Florida Cohort, which enrolled adult PWH from community-based clinics included information on predisposing (demographics), enabling (transportation, income), and need (ART adherence <90%) factors. ART preference was assessed via a single question (prefer pills, quarterly LAI, or no preference). Confounder-adjusted multinomial logistic regressions compared those who preferred pills to the other preference options, with covariates identified using directed acyclic graphs. Overall, 314 participants responded (40% non-Hispanic Black, 62% assigned male, 63% aged 50+). Most (63%) preferred the hypothetical LAI, 23% preferred pills, and 14% had no preference. PWH with access to a car (aRRR 1.97 95%CI 1.05-3.71), higher income (aRRR 2.55 95%CI 1.04-6.25), and suboptimal ART adherence (aRRR 7.41 95% CI 1.52-36.23) were more likely to prefer the LAI, while those who reported having no social network were less likely to prefer the LAI (aRRR 0.32 95% CI 0.11-0.88). Overall LAI interest was high, with greater preference associated with enabling and need factors.

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