boxazomycin A 的抗菌和作用机制研究。

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Antibiotics Pub Date : 2024-08-01 DOI:10.1038/s41429-024-00757-9

Sheo B. Singh, James Occi, John Ondeyka, John F. Barrett, Prakash Masurekar, Mary Motyl, Charles Gill, Gino Salituro

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引用次数: 0

摘要

盒唑霉素 A-C 是 1987 年从放线菌菌株 G495-1 中分离出来的强效广谱抗生素。我们现在报告说，博azomycin A 通过选择性抑制蛋白质合成来抑制细菌生长，它具有抑菌作用，而且对耐药菌株同样有效。没有观察到对蛋白质合成抑制剂的交叉耐药性，这表明它的抑制作用不同于临床上的蛋白质合成抑制剂。我们还报告了在金黄色葡萄球菌小鼠感染模型中的体内疗效，并辅以相应的药代动力学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antibacterial and mechanism of action studies of boxazomycin A

Boxazomycins A-C are potent broad-spectrum antibiotics isolated from Actinomycetes strain G495-1 in 1987. We now report that boxazomycin A inhibits bacterial growth by selectively inhibiting protein synthesis, its effect is bacteriostatic, and it is equally active against drug resistant bacterial strains. No cross-resistance to protein synthesis inhibitors was observed suggesting that its inhibition is distinct from clinical protein synthesis inhibitors. We also report in vivo efficacy in a Staphylococcus aureus murine infection model supported by corresponding pharmacokinetic studies.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.