Thuy Anh Bui, Haoqi Mei, Rui Sang, David Gallego Ortega, Wei Deng
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引用次数: 0
摘要
嵌合抗原受体(CAR)T 细胞疗法已成为治疗癌症的一种突破性免疫疗法。为了克服目前体外 CAR T 细胞疗法产品的复杂性和高制造成本,近年来开发出了直接在体内制造 CAR T 细胞的替代策略。这些策略包括通过工程纳米载体或病毒载体直接注入 CAR 基因,在原位生成 CAR T 细胞。本综述全面概述了原位生成 T 细胞靶向 CAR 的最新进展。此外,它还指出了与体内 CAR T 方法相关的挑战以及克服这些问题的潜在策略。
Advancements and challenges in developing in vivo CAR T cell therapies for cancer treatment.
The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and high manufacturing cost associated with current ex vivo CAR T cell therapy products, alternative strategies to produce CAR T cells directly in the body have been developed in recent years. These strategies involve the direct infusion of CAR genes via engineered nanocarriers or viral vectors to generate CAR T cells in situ. This review offers a comprehensive overview of recent advancements in the development of T cell-targeted CAR generation in situ. Additionally, it identifies the challenges associated with in vivo CAR T method and potential strategies to overcome these issues.
EBioMedicineBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
17.70
自引率
0.90%
发文量
579
审稿时长
5 weeks
期刊介绍:
eBioMedicine is a comprehensive biomedical research journal that covers a wide range of studies that are relevant to human health. Our focus is on original research that explores the fundamental factors influencing human health and disease, including the discovery of new therapeutic targets and treatments, the identification of biomarkers and diagnostic tools, and the investigation and modification of disease pathways and mechanisms. We welcome studies from any biomedical discipline that contribute to our understanding of disease and aim to improve human health.