胎位不正与母体在 4-6 胎龄感染 SARS-CoV-2 之间的关系。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Med Pub Date : 2024-08-01 DOI:10.1016/j.medj.2024.07.009
Zhenming Guo, Yingchun Luo, Yan Bi, Liangjie Liu, Yuan Qi, Jin Yan, Chunhai Cai, Chenxiang Xi, Yihan Tan, Shifa Yao, Yanhui Qu, Ping Chen, Jiayu Chen, Yanlin Wang, Xiao Mao, Baoying Ye, Shaorong Gao, Guang He, Shan Bian
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引用次数: 0

摘要

背景:在2022年12月中国发生严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2)疫情后的几个月里,超声诊断出胎儿坐位不正的人数急剧增加,这促使我们研究母体感染SARS-CoV-2是否与胎儿坐位不正的风险升高有关:在这项以医院为基础的多机构配对病例对照研究中,我们调查了在本院孕 20-24 周接受超声胎儿生物特征评估的孕妇。每名怀有坐位倒置胎儿的孕妇根据分娩日期随机与四名对照组进行配对。收集了相关信息,包括 SARS-CoV-2 感染和其他潜在风险因素。采用条件逻辑回归法检验胎儿坐位不正与不同孕周的 SARS-CoV-2 感染及个体风险因素之间可能存在的关联:我们共登记了 52 名在 2023 年 1 月 1 日至 10 月 31 日期间被诊断为胎位不正的孕妇和 208 名胎儿正常的匹配对照者。我们没有发现胎儿坐位不正的风险增加与妊娠期感染 SARS-CoV-2 或其他风险因素有关。然而,在调整协变量后,胎儿坐位不正与妊娠 4-6 周感染 SARS-CoV-2 显著相关(调整后的几率比 [aOR] 6.54 [95% 置信区间 1.76-24.34]),但与其他妊娠期感染无关:结论:胎儿坐位不正的风险增加与母体在孕4-6周感染SARS-CoV-2有显著相关性,而孕4-6周正是人类内脏侧位的胎儿发育窗口期:国家重点研发计划等
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Association between situs inversus and maternal SARS-CoV-2 infection at gestational age 4-6 weeks.

Background: A dramatic increase in fetal situs inversus diagnoses by ultrasound in the months following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surge of December 2022 in China led us to investigate whether maternal SARS-CoV-2 exposure could be associated with elevated risk of fetal situs inversus.

Methods: In this multi-institutional, hospital-based, matched case-control study, we investigated pregnant women who underwent ultrasonographic fetal biometric assessment at gestational weeks 20-24 at our hospitals. Each pregnant woman carrying a situs inversus fetus was randomly matched with four controls based on the date of confinement. Relevant information, including SARS-CoV-2 infection, and other potential risk factors were collected. Conditional logistic regression was used to test possible associations between fetal situs inversus and SARS-CoV-2 infection at different gestational weeks as well as individual risk factors.

Findings: A total of 52 pregnant women diagnosed with fetal situs inversus between January 1 and October 31, 2023 and 208 matched controls with normal fetuses were enrolled. We found no association between an increased risk of fetal situs inversus with gestational SARS-CoV-2 infection or with other risk factors. However, fetal situs inversus was significantly associated with SARS-CoV-2 infection specifically in gestational weeks 4-6 (adjusted odds ratio [aOR] 6.54 [95% confidence interval 1.76-24.34]), but not with infection at other gestational ages, after adjusting for covariates.

Conclusions: Increased risk of fetal situs inversus is significantly associated with maternal SARS-CoV-2 infection at gestational weeks 4-6, corresponding to the fetal developmental window for visceral lateralization in humans.

Funding: National Key R&D Program of China, etc.

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来源期刊
Med
Med MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
17.70
自引率
0.60%
发文量
102
期刊介绍: Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.
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