分解 p53 的代谢活性和肿瘤抑制活性。

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 DOI:10.1016/j.tem.2024.07.018

Yoshitaka Sakurai, Naoto Kubota, Takashi Kadowaki

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引用次数: 0

摘要

肿瘤抑制因子 p53 可调节代谢平衡。最近，Tsaousidou 等人报告说，尽管存在肥胖和胰岛素抵抗，但通过下调 Tudor 交互修复调节因子（TIRR）选择性地激活 p53，可获得抗癌保护，这为了解 p53 在肿瘤发生和系统代谢交汇处的作用提供了新的视角。

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Dissociating the metabolic and tumor-suppressive activity of p53.

The tumor suppressor p53 regulates metabolic homeostasis. Recently, Tsaousidou et al. reported that selective activation of p53 via downregulation of Tudor interacting repair regulator (TIRR) confers protection against cancer despite obesity and insulin resistance, providing new insights into the role of p53 at the intersection of oncogenesis and systemic metabolism.

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

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审稿时长

82 days

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